Drug Index

Beclomethasone

 
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Mechanism :

Beclomethasone dipropionate is a diester of beclomethasone, a synthetic corticosteroid chemically related to dexamethasone. Corticosteroids have multiple anti-inflammatory effects, inhibiting both inflammatory cells and release of inflammatory mediators. It is presumed that these anti-inflammatory actions play an important role in the efficacy of beclomethasone dipropionate in controlling symptoms and improving lung function in asthma.


Indication :

• Prophylaxis of asthma

• Prophylaxis and treatment of allergic rhinitis


Contraindications :

Beclomethasone can occasionally cause paradoxical bronchospasm. Use with caution in respiratory infection.


Dosing :

Nasal Inhalation for allergic rhinitis: 1 puff = 50 mcg.

1-2 inhalations in each nostril twice daily.

Oral inhalation for asthma:

5 to 12 years: 50 mcg inhaled twice daily. Maximum dose: 100 mcg twice daily.

>12 years: 50-100 mcg inhaled twice daily. Maximum dose: 400 mcg twice daily.


Adverse Effect :

Urticaria, angioedema, rash, and bronchospasm, systemic adrenal suppression, oral candidiasis (with inhalers).


Interaction :

Interactions like other corticosteroids amongst which the most significant recently is:
Inhaled corticosteroids are substrates of hepatic CYP3A4 and have the potential to interact with ritonavir. These interactions can result in steroid accumulation, adrenal suppression and Cushing's syndrome.


08/10/2019 20:44:14 Beclomethasone
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