Drug Index

Prednicarbate

 
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Mechanism :

In common with other topical corticosteroids, prednicarbate has anti-inflammatory, antipruritic, and vasoconstrictive properties. In general, the mechanism of the anti-inflammatory activity of topical steroids is unclear. However, corticosteroids are thought to act by the induction of phospholipase A2 inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A2.


Indication :

• Pruritic manifestations

• Corticosteroid responsive dermatoses.


Contraindications :

Pregnant, planning to become pregnant, or are breast-feeding.

Taking any prescription or non-prescription medicine, herbal preparation, or dietary supplement.

Allergies to medicines, foods, or other substances.

Any kind of skin infection, cuts, scrapes, or lessened blood flow to your skin.

Had a recent vaccination; have measles, tuberculosis (TB), chickenpox, or shingles; or a positive TB test.

Taking an oral corticosteroid (e.g., prednisone) or similar medicines.


Dosing :

Available as 0.1% cream/ointment

<12 months: Safety and efficacy not established.

>12 months: Apply cream twice daily.

>10 years: Apply ointment twice daily.

Do not use beyond 3 weeks.


Adverse Effect :

Burning, itching, drying, scaling, or cracking of the skin, irritation of the skin, pain,

raised, dark red, or wart-like spots on the skin, especially when used on the face,

shininess of the skin, thinning of the skin with easy bruising, especially when used on the face or where the skin folds together (e.g., between the fingers). HPA suppression with use of higher potency for >2 weeks.


Interaction :

No data regarding the interactions of Prednicarbate was found.


08/11/2019 20:40:31 Prednicarbate
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