Drug Index

Benzyl Penicillin

 
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Synonym :

Penicillin G

Mechanism :

It is also known as Penicillin G; Penicillin G exerts a bactericidal action against penicillin-susceptible microorganisms during the stage of active multiplication. It acts through the inhibition of biosynthesis of cell-wall mucopeptide. It is not active against the penicillinase-producing bacteria, which include many strains of staphylococci.


Indication :

• Streptococcal throat infections e.g., pharyngitis.

• Cellulitis

• Impetigo

• Erysipelas

• Septic Arthritis

• Osteomyelitis

• Endocarditis

• Anthrax

• Congenital syphilis

• Leptospirosis


Contraindications :

A history of a previous hypersensitivity reaction to any of the penicillin’s is a contraindication.


Dosing :

IV/IM

Mild infection: 50,000 units/kg/dose 8 hourly for 7-10 days.

Moderate infection: 50,000 units/kg/dose 6 hourly for 10-14 days.

Severe infection like endocarditis: 50,000 units/kg/dose 4 hourly for 10-14 days. Max: 24 million units/day.

Congenital Syphilis:

<7 days: 50,000 units/kg/dose IV every 12 hours for 7 days and then every 8 hours for next 3 days.

>7 days: 50,000 units/kg/dose IV every 8 hours for 10 days.

Anthrax:

Neonates: 50,000 units/kg/dose every 6 hours for 2 weeks.

>1 month of age: 100,000 units/kg/dose every 6 hours for 2 weeks.


Adverse Effect :

Maculopapular eruptions, exfoliative dermatitis, urticaria, Jarisch-Herxheimer reaction, anaphylaxis, laryngeal edema, serum-sickness like reactions (chills, fever, edema, arthralgia, prostration, eosinophilia), hemolytic anemia, leukopenia, thrombocytopenia.


Interaction :

Tetracycline: May antagonize the bactericidal effect of penicillin, and concurrent use of these drugs should be avoided.
Probenecid: Prolongs serum penicillin levels by slowing the rate of excretion by competitively inhibiting renal tubular secretion of penicillin.


07/21/2019 21:52:03 Benzyl Penicillin
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