Drug Index

Bismuth Subcitrate

Synonym :


Mechanism :

It is a gastric ulcer healing drug used in combination with other drugs such as ranitidine in the treatment of peptic ulcers. It forms a protective coat over the gastric mucosa and the ulcer base. It also has an inhibitory effect on H. Pylori.

Indication :

  • Symptomatic treatment of mild, non-specific diarrhea including traveller’s diarrhea, chronic infantile diarrhea.
  • Adjunctive treatment of Helicobacter pylori-associated antral gastritis.

Contraindications :

Hypersensitivity to bismuth; history of GI bleeding or coagulopathy.

Dosing :

10 mg/kg/day PO in 2 divided doses half hour before meals.

Adverse Effect :

Darkening of tongue or stools, nausea, vomiting, bone and joint toxicity, fatal encephalopathy in patients with renal impairment or if given over prolonged periods.

Interaction :

It decreases absorption of tetracycline: Increases toxicity of aspirin (due to absorption of salicylates), warfarin, hypoglycemics.

Hepatic Dose :

No dosage adjustments are recommended.
02/21/2024 00:55:11 Bismuth Subcitrate
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