Drug Index

Brivaracetam

 
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Mechanism :

Brivaracetam displays a high and selective affinity for synaptic vesicle protein 2A (SV2A) in the brain, which may contribute to the antiepileptic effect.


Indication :

• Partial-onset seizures: Treatment of partial-onset seizures in patients with epilepsy as monotherapy or adjunctive therapy.


Contraindications :

Hypersensitivity to brivaracetam or any component of the formulation.


Dosing :

Children ≥4 years and Adolescents <16 years: Oral:

11 to <20 kg: Initial: 0.5 to 1.25 mg/kg twice daily; may increase up to a maximum of 2.5 mg/kg twice daily based on individual patient response and tolerability.

20 to <50 kg: Initial: 0.5 to 1 mg/kg twice daily; may increase up to a maximum of 2 mg/kg twice daily based on individual patient response and tolerability.

≥50 kg: Initial: 25 to 50 mg twice daily; may increase up to a maximum of 100 mg twice daily based on individual patient response and tolerability.


Adverse Effect :

Drowsiness, fatigue, hypersomnia, lethargy, abnormal gait, ataxia, dizziness, psychiatric disturbance, asthenia, nystagmus, decreased WBC, nausea, vomiting, infusion site pain.


Interaction :

CNS Depressants: May enhance the adverse/toxic effect of other CNS Depressants.
CYP2C19 Inducers: May increase the metabolism of CYP2C19 Substrates.
Levetiracetam: May diminish the therapeutic effect of Brivaracetam.
Orlistat: May decrease the serum concentration of Anticonvulsants.
Opioid Analgesics: CNS Depressants may enhance the CNS depressant effect of Opioid Analgesics.
Selective Serotonin Reuptake Inhibitors: CNS Depressants may enhance the adverse/toxic effect of Selective Serotonin Reuptake Inhibitors.


07/15/2019 05:42:44 Brivaracetam
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