Drug Index

Calcitonin

 
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Mechanism :

Calcitonin is a polypeptide hormone secreted by the parafollicular cells of the thyroid gland in mammals. Calcitonin acts primarily on bone, but direct renal effects and actions on the gastrointestinal tract are also recognized.


Indication :

• Osteogenesis imperfecta

• Hypercalcemia


Contraindications :

Clinical allergy to calcitonin-salmon. For patients with suspected sensitivity to calcitonin, skin testing should be considered prior to treatment utilizing a dilute, sterile solution of a calcitonin-salmon injectable product.


Dosing :

Osteogenesis imperfecta:

>6 months: IM, SC: 2 units/kg/dose 3 times/week.


Adverse Effect :

Flushing of face, edema, dizziness, headache, chills, rash, nausea, vomiting, diarrhea, anorexia, metallic taste, inflammatory reactions at injection site, weakness, tingling of palms and soles, back and joint pain, diuresis, shortness of breath, hypersensitivity reactions.


Interaction :

Cardiac glycosides: Calcitonin may cause serum calcium levels to fall transiently to below normal levels, and therefore dose adjustment of cardiac glycosides may be necessary.



Renal Dose :

Dose in Renal Impairment GFR (mL/min)
20-50Dose as in normal renal function
10-20Dose as in normal renal function
<10Dose as in normal renal function

Dose in Patients undergoing Renal Replacement Therapies
CAPDUnlikely to be dialysed. Dose as in normal renal function
HDUnlikely to be dialysed. Dose as in normal renal function
HDF/High fluxUnlikely to be dialysed. Dose as in normal renal function
CAV/VVHDUnlikely to be dialysed. Dose as in normal renal function

Hepatic Dose :

No dosage adjustments are recommended.
05/22/2020 17:23:24 Calcitonin
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