Drug Index


Mechanism :

Inhibits bacterial cell wall synthesis by binding to one or more of the penicillin-binding proteins (PBPs)

Indication :

  • Bone and joint infections
  • Intra-abdominal infections
  • Skin and skin structure infections
  • Urinary tract infections

Contraindications :

Hypersensitivity to cefotetan, any component of the formulation, or other cephalosporins; previous cephalosporin-associated hemolytic anemia.

Dosing :

Mild to moderate infection:
30 mg/kg/dose every 12 hours. Maximum dose: 4,000 mg/day.
Severe infection:
50 mg/kg/dose every 12 hours (usual maximum dose: 4,000 mg/day; for life-threatening infections doses as high as 3,000 mg every 12 hours [6,000 mg/day] have been used).
Intra-abdominal infection, complicated (off-label use):
20 to 40 mg/kg/dose every 12 hours.

Adverse Effect :

Diarrhea, increased serum transaminases, hypersensitivity reaction, agranulocytosis, anaphylaxis, eosinophilia, fever, hemolytic anemia, hemorrhage, increased blood urea nitrogen, increased serum creatinine, leukopenia, nausea, nephrotoxicity, phlebitis, prolonged prothrombin time, pruritus, pseudomembranous colitis, skin rash.

Interaction :

Alcohol (Ethyl): Cefotetan may enhance the adverse/toxic effect of Alcohol.

Sodium Picosulfate: Antibiotics may diminish the therapeutic effect of Sodium Picosulfate.
Vitamin K Antagonists (e.g., Warfarin): Cephalosporins may enhance the anticoagulant effect of Vitamin K Antagonists.

Hepatic Dose :

No dosage adjustments are recommended.
03/13/2024 06:13:29 Cefotetan
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