Drug Index

Cefotetan

 
print

Mechanism :

Inhibits bacterial cell wall synthesis by binding to one or more of the penicillin-binding proteins (PBPs)


Indication :

• Bone and joint infections

• Intra-abdominal infections

• Skin and skin structure infections

• Urinary tract infections


Contraindications :

Hypersensitivity to cefotetan, any component of the formulation, or other cephalosporins; previous cephalosporin-associated hemolytic anemia.


Dosing :

IM, IV

Mild to moderate infection:30 mg/kg/dose every 12 hours. Maximum dose: 4,000 mg/day.

Severe infection:50 mg/kg/dose every 12 hours (usual maximum dose: 4,000 mg/day; for life-threatening infections doses as high as 3,000 mg every 12 hours [6,000 mg/day] have been used).

Intra-abdominal infection, complicated (off-label use):20 to 40 mg/kg/dose every 12 hours.


Adverse Effect :

Diarrhea, increased serum transaminases, hypersensitivity reaction, agranulocytosis, anaphylaxis, eosinophilia, fever, hemolytic anemia, hemorrhage, increased blood urea nitrogen, increased serum creatinine, leukopenia, nausea, nephrotoxicity, phlebitis, prolonged prothrombin time, pruritus, pseudomembranous colitis, skin rash.


Interaction :

Alcohol (Ethyl): Cefotetan may enhance the adverse/toxic effect of Alcohol.

Sodium Picosulfate: Antibiotics may diminish the therapeutic effect of Sodium Picosulfate.
Vitamin K Antagonists (e.g., Warfarin): Cephalosporins may enhance the anticoagulant effect of Vitamin K Antagonists.


07/18/2019 01:53:54 Cefotetan
ask a doctor
Ask a Doctor
Disclaimer: The information given by www.pediatriconcall.com is provided by medical and paramedical & Health providers voluntarily for display & is meant only for informational purpose. The site does not guarantee the accuracy or authenticity of the information. Use of any information is solely at the user's own risk. The appearance of advertisement or product information in the various section in the website does not constitute an endorsement or approval by Pediatric Oncall of the quality or value of the said product or of claims made by its manufacturer.
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0