Drug Index

Ceftaroline

 
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Mechanism :

Inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs) 1 through 3.


Indication :

• Treatment of community-acquired bacterial pneumonia

• Skin and skin structure infections


Contraindications :

Known serious hypersensitivity to ceftaroline, other members of the cephalosporin class, or any component of the formulation.


Dosing :

IV

≥2 months to <2 years: 8 mg/kg/dose every 8 hours for 5 to 14 days.

≥2 years to <18 years:

≤33 kg: 12 mg/kg/dose every 8 hours for 5 to 14 days.

>33 kg: 400 mg every 8 hours or 600 mg every 12 hours for 5 to 14 days.


Adverse Effect :

Positive direct Coombs test, bradycardia, palpitations. phlebitis, insomnia, headache, seizures, skin rash, pruritus, hypokalemia, hyperglycemia, diarrhea, vomiting, nausea, anemia, eosinophilia, neutropenia, thrombocytopenia, increased serum ALT and AST, anaphylaxis.


Interaction :

Probenecid: May increase the serum concentration of Cephalosporins.
Vitamin K Antagonists (e.g., warfarin): Cephalosporins may enhance the anticoagulant effect of Vitamin K Antagonists.


07/13/2019 01:22:24 Ceftaroline
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