Drug Index


Mechanism :

Inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs) 1 through 3.

Indication :

  • Treatment of community-acquired bacterial pneumonia
  • Skin and skin structure infections

Contraindications :

Known serious hypersensitivity to ceftaroline, other members of the cephalosporin class, or any component of the formulation.

Dosing :

IV ≥2 months to <2 years:
8 mg/kg/dose every 8 hours for 5 to 14 days.
IV ≥2 years to <18 years:
≤33 kg:
12 mg/kg/dose every 8 hours for 5 to 14 days.
>33 kg:
400 mg every 8 hours or 600 mg every 12 hours for 5 to 14 days.

Adverse Effect :

Positive direct Coombs test, bradycardia, palpitations. phlebitis, insomnia, headache, seizures, skin rash, pruritus, hypokalemia, hyperglycemia, diarrhea, vomiting, nausea, anemia, eosinophilia, neutropenia, thrombocytopenia, increased serum ALT and AST, anaphylaxis.

Interaction :

Probenecid: May increase the serum concentration of Cephalosporins.
Vitamin K Antagonists (e.g., warfarin): Cephalosporins may enhance the anticoagulant effect of Vitamin K Antagonists.

Hepatic Dose :

No dosage adjustments are recommended.
12/20/2023 07:44:39 Ceftaroline
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