Drug Index

Ceftazidime/Avibactum

 
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Mechanism :

Ceftazidime inhibits bacterial cell wall synthesis by binding to one or more of the penicillin-binding proteins (PBPs).
Avibactam inactivates some beta-lactamases and protects ceftazidime from degradation.


Indication :

• Complicated intra-abdominal infections

• Pneumonia, hospital-acquired and ventilator-associated

• Complicated Urinary tract infections


Contraindications :

Known serious hypersensitivity to ceftazidime, avibactam, other cephalosporins, or any component of the formulation.


Dosing :

<18 years: Safety and efficacy not established.

>18 years: 2.5 g (2 g/0.5 g) IV q8hr infused over 2 hours for 5-14 days.


Adverse Effect :

Positive direct coombs test, pruritus, vomiting, diarrhea, nausea, constipation.


Interaction :

Chloramphenicol: May diminish the therapeutic effect of Ceftazidime.
Probenecid: May increase the serum concentration of Avibactam.
Tolvaptan: May increase the serum concentration of OAT3 Substrates.
Vitamin K Antagonists (e.g., Warfarin): Cephalosporins may enhance the anticoagulant effect of Vitamin K Antagonists.


07/19/2019 03:08:43 Ceftazidime/Avibactum
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