Drug Index


Mechanism :

Ceftazidime inhibits bacterial cell wall synthesis by binding to one or more of the penicillin-binding proteins (PBPs).
Avibactam inactivates some beta-lactamases and protects ceftazidime from degradation.

Indication :

  • Complicated intra-abdominal infections
  • Pneumonia, hospital-acquired and ventilator-associated
  • Complicated Urinary tract infections

Contraindications :

Known serious hypersensitivity to ceftazidime, avibactam, other cephalosporins, or any component of the formulation.

Dosing :

<18 years:
Safety and efficacy not established.
>18 years:
2.5 g (2 g/0.5 g) IV q8hr infused over 2 hours for 5-14 days.

Adverse Effect :

Positive direct coombs test, pruritus, vomiting, diarrhea, nausea, constipation.

Interaction :

Chloramphenicol: May diminish the therapeutic effect of Ceftazidime.
Probenecid: May increase the serum concentration of Avibactam.
Tolvaptan: May increase the serum concentration of OAT3 Substrates.
Vitamin K Antagonists (e.g., Warfarin): Cephalosporins may enhance the anticoagulant effect of Vitamin K Antagonists.

Hepatic Dose :

No dosage adjustments are recommended.
02/20/2024 23:49:02 Ceftazidime/Avibactum
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