Drug Index

Ceftazidime

Mechanism :

Ceftazidime is a semisynthetic, broad-spectrum, beta-lactam antibiotic for parenteral administration. Cephalosporins are bactericidal because of their inhibition of cell-wall synthesis.


Indication :

  • Pseudomonas infection

Contraindications :

Ceftazidime is contraindicated in patients with known allergy to the cephalosporin group of antibiotics.


Dosing :

Neonates:
<7 days or those >7 days but <1200 gm: 50 mg/kg/dose IM/IV every 12 hourly.
>7 days: 50 mg/kg/dose IM/IV every 8 hourly.
1 month-12 years: 30-50 mg/kg IV every 8 hours; maximum dose: 6 g/day.
>12 years: 1-2 g IV every 8 hours.

Adverse Effect :

Phlebitis, pruritus, rash, fever, toxic epidermal necrolysis, Stevens-Johnson syndrome, erythema multiforme, diarrhea, nausea, vomiting and abdominal pain.


Interaction :

Nephrotoxicity: Concomitant administration of cephalosporins with aminoglycoside antibiotics or potent diuretics such as furosemide.
Chloramphenicol: Antagonistic to beta-lactam antibiotics, including ceftazidime.



Renal Dose :

Dose in Renal Impairment GFR (mL/min)
31-501-2 g every 12 hours
16-301-2 g every 24 hours
6-15500 mg – 1 g every 24 hours
<5500 mg - 1 g every 48 hours

Dose in Patients undergoing Renal Replacement Therapies
CAPDDialysed. 500 mg – 1 g every 24 hours
HDDialysed. 500 mg – 1 g every 24–48 hours
HDF/High fluxDialysed. 500 mg – 1 g every 24–48 hours
CAV/VVHDDialysed. 2 g every 8 hours1 or 1–2 g every 12 hours
CVVHD/HDFDialysed. 2 g every 12 hours3

Hepatic Dose :

No dosage adjustments are recommended.
08/12/2024 19:18:17 Ceftazidime
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