Drug Index

Cefadroxil

 
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Mechanism :

Cefadroxil is a semisynthetic first-generation cephalosporin antibiotic more effective against gram positive bacteria intended for oral administration for skin infections and respiratory tract infections. Cephalosporins are bactericidal because of their inhibition of cell-wall synthesis.


Indication :

• Respiratory tract infections

• Pyoderma

• Otitis media

• Pyelonephritis

• Cystitis

• Urethritis


Contraindications :

Cefadroxil is contraindicated in patients with known allergy to the cephalosporin group of antibiotics.


Dosing :

Oral 30 mg/kg/24 hours in 2 divided doses for 10 days. Max: 1 gm/dose.

Endocarditis prophylaxis: 50 mg/kg 1 hour before procedure (dental) orally. Max: 2 g.


Adverse Effect :

Pseudomembranous colitis, dyspepsia, nausea and vomiting, diarrhea, rash, urticaria, angioedema, pruritus, hepatic dysfunction, moderate transient neutropenia, fever, agranulocytosis, thrombocytopenia, erythema multiforme, Stevens-Johnson syndrome, serum sickness, arthralgia.


Interaction :

Cephalosporin: Positive direct Coombs tests have been reported during treatment with the cephalosporin antibiotics.
Probenecid: Prolongs serum penicillin levels by slowing the rate of excretion by competitively inhibiting renal tubular secretion.


08/11/2019 20:49:12 Cefadroxil
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