Drug Index

Cefprozil

 
print

Mechanism :

Cefprozil is a semisynthetic broad-spectrum cephalosporin antibiotic intended for oral administration. It has in vitro activity against a broad range of gram positive and gram-negative bacteria. The bactericidal action of cefprozil results from inhibition of cell-wall synthesis.


Indication :

• Pharyngitis/tonsillitis

• Otitis media

• Acute sinusitis

• Uncomplicated skin and soft tissue infections


Contraindications :

In patients with known allergy to the cephalosporin class of antibiotics or to any component of the cefprozil preparations.


Dosing :

2 to 12 years: 15-30 mg/kg/day (Orally) every 12 hours daily for 10 days.

Max dose: 1 g/day.

13 years and older: 250-500 mg (Orally) every 12 hours daily for 10 days.


Adverse Effect :

Diarrhea, nausea, vomiting, abdominal pain, pseudomembranous colitis, elevations of AST/ALT, alkaline phosphatase, bilirubin, hypersensitivity (rash, urticaria, anaphylaxis, angioedema), serum-sickness like reactions, Stevens-Johnson syndrome, dizziness, hyperactivity, headache, insomnia, decreased leukocyte count, eosinophilia, elevated BUN, serum creatinine, thrombocytopenia.


Interaction :

Aminoglycoside and cephalosporin antibiotics: Nephrotoxicity has been reported following concomitant administration of aminoglycoside antibiotics and cephalosporin antibiotics.
Probenecid: Concomitant administration of probenecid doubled the AUC for cefprozil.

The bioavailability of the capsule formulation of cefprozil was not affected when administered 5 minutes following an antacid.
Drug/Laboratory Test Interactions: Cephalosporin antibiotics may produce a false positive reaction for glucose in the urine with copper reduction tests (Benedict's or Fehling's solution or with Clinitest tablets), but not with enzyme-based tests for glycosuria. A false negative reaction may occur in the ferricyanide test for blood glucose. The presence of cefprozil in the blood does not interfere with the assay of plasma or urine creatinine by the alkaline picrate method.


08/11/2019 21:01:01 Cefprozil
ask a doctor
Ask a Doctor
Disclaimer: The information given by www.pediatriconcall.com is provided by medical and paramedical & Health providers voluntarily for display & is meant only for informational purpose. The site does not guarantee the accuracy or authenticity of the information. Use of any information is solely at the user's own risk. The appearance of advertisement or product information in the various section in the website does not constitute an endorsement or approval by Pediatric Oncall of the quality or value of the said product or of claims made by its manufacturer.
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0