Drug Index

Ceftazidime

 
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Mechanism :

Ceftazidime is a semisynthetic, broad-spectrum, beta-lactam antibiotic for parenteral administration. Cephalosporins are bactericidal because of their inhibition of cell-wall synthesis.


Indication :

• Pseudomonas infection


Contraindications :

Ceftazidime is contraindicated in patients with known allergy to the cephalosporin group of antibiotics.


Dosing :

Neonates: <7 days or those >7 days but <1200 gm: 50 mg/kg/dose IM/IV every 12 hourly.

>7 days: 50 mg/kg/dose IM/IV every 8 hourly.

1 month-12 years: 30-50 mg/kg IV every 8 hours; maximum dose: 6 g/day.

>12 years: 1-2 g IV every 8 hours.


Adverse Effect :

Phlebitis, pruritus, rash, fever, toxic epidermal necrolysis, Stevens-Johnson syndrome, erythema multiforme, diarrhea, nausea, vomiting and abdominal pain.


Interaction :

Nephrotoxicity: Concomitant administration of cephalosporins with aminoglycoside antibiotics or potent diuretics such as furosemide.
Chloramphenicol: Antagonistic to beta-lactam antibiotics, including ceftazidime.


08/11/2019 21:05:41 Ceftazidime
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