Drug Index

Ceftizoxime

 
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Mechanism :

The bactericidal action of ceftizoxime results from inhibition of cell-wall synthesis. Cefizox is highly resistant to a broad spectrum of beta-lactamases. It is active against Klebsiella; Proteus mirabilis; Escherichia coli; Haemophilus influenzae including ampicillin-resistant strains; Staphylococcus aureus (penicillinase- and non-penicillinase-producing); Serratia spp.; Enterobacter spp.; Bacteroides spp.; and Streptococcus spp. including S. pneumoniae.


Indication :

• Lower respiratory tract infections

• Urinary tract infections

• Intra-abdominal infections

• Septicemia

• Skin and soft tissue infections

• Bone and joint infections


Contraindications :

Documented hypersensitivity.


Dosing :

Neonates (off-label): 25-50 mg/kg IV every 12 hours.

<6 months old (off-label): 100-200 mg/kg/day IV divided every 8 hourly.

>6 months old: 150-200 mg/kg/day IV divided every 6-8 hourly; maximum dose: 12 g/day.


Adverse Effect :

Fever, pruritus, skin rash, leukopenia, thrombocytopenia, rise in liver enzymes and blood urea.


Interaction :

Live vaccines: Decrease the effect of the vaccines by pharmacodynamic synergism.


08/09/2019 09:40:58 Ceftizoxime
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