Drug Index

Cholic Acid

 
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Mechanism :

Cholic acid, a primary bile acid, enhances bile flow and provides the physiologic feedback inhibition of bile acid synthesis to maintain bile acid homeostasis.


Indication :

• Bile acid synthesis disorders

• Peroxisomal disorders


Contraindications :

No contraindications.


Dosing :

Oral

≥3 weeks: 10 to 15 mg/kg (once daily or in 2 divided doses); administer 11 to 17 mg/kg (once daily or in 2 divided doses) in patients with concomitant familial hypertriglyceridemia.


Adverse Effect :

Cholestasis, hyperbilirubinemia, increased serum transaminases, malaise, peripheral neuropathy, diarrhea, abdominal pain, intestinal polyps, UTI, jaundice, cholelithiasis.


Interaction :

Aluminium Hydroxide: May decrease the absorption of Cholic Acid.
Bile Acid Sequestrants: May decrease the absorption of Cholic Acid.
BSEP/ABCB11 Inhibitors: May decrease the excretion of Cholic Acid.
Sevelamer: May decrease the absorption of Cholic Acid.
Sucralfate: May decrease the absorption of Cholic Acid.


07/21/2019 21:54:25 Cholic Acid
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