Drug Index

Cinacalcet

 
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Mechanism :

Increases the sensitivity of the calcium-sensing receptor on the parathyroid gland


Indication :

• Hyperparathyroidism, primary and secondary

• Parathyroid carcinoma


Contraindications :

Serum calcium less than the lower limit of normal range.


Dosing :

Safety and efficacy not established in pediatric population.

Adults: Initial dose: 30 mg PO OD. May increase at 2-4 week intervals by 30 mg.

Max dose: 180 mg daily.


Adverse Effect :

Diarrhea, nausea, vomiting, myalgia, dizziness, hypertension, anorexia, asthenia, seizures.


Interaction :

CYP2D6 Substrates: CYP2D6 Inhibitors may decrease the metabolism of CYP2D6 Substrates.
CYP3A4 Inhibitors: May decrease the metabolism of CYP3A4 Substrates.
Etelcalcetide: Cinacalcet may enhance the hypocalcemic effect of Etelcalcetide.
Tricyclic Antidepressants: Cinacalcet may increase the serum concentration of Tricyclic Antidepressants.


07/14/2019 19:31:41 Cinacalcet
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