Drug Index


Mechanism :

Increases the sensitivity of the calcium-sensing receptor on the parathyroid gland

Indication :

  • Hyperparathyroidism, primary and secondary
  • Parathyroid carcinoma

Contraindications :

Serum calcium less than the lower limit of normal range.

Dosing :

Safety and efficacy not established in pediatric population.
Initial dose:
30 mg PO OD. May increase at 2-4 week intervals by 30 mg.
Max dose:
180 mg daily.

Adverse Effect :

Diarrhea, nausea, vomiting, myalgia, dizziness, hypertension, anorexia, asthenia, seizures.

Interaction :

CYP2D6 Substrates: CYP2D6 Inhibitors may decrease the metabolism of CYP2D6 Substrates.
CYP3A4 Inhibitors: May decrease the metabolism of CYP3A4 Substrates.
Etelcalcetide: Cinacalcet may enhance the hypocalcemic effect of Etelcalcetide.
Tricyclic Antidepressants: Cinacalcet may increase the serum concentration of Tricyclic Antidepressants.

Renal Dose :

Dose in Renal Impairment GFR (mL/min)
20-50Dose as in normal renal function
10-20Dose as in normal renal function
<10Dose as in normal renal function

Dose in Patients undergoing Renal Replacement Therapies
CAPDNot dialysed. Dose as in normal renal function
HDNot dialysed. Dose as in normal renal function
HDF/High fluxUnlikely to be dialysed. Dose as normal renal function
CAV/VVHDNot dialysed. Dose as in normal renal function

Hepatic Dose :

Moderate to severe hepatic impairment: Reduction in dose may be required. Parathyroid hormone and serum calcium concentrations should be closely monitored.
11/01/2020 12:13:11 Cinacalcet
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