Drug Index

Cosyntropin

 
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Mechanism :

Stimulates the adrenal cortex to secrete adrenal steroids (including hydrocortisone, cortisone), androgenic substances, and a small amount of aldosterone


Indication :

• Screening of adrenocortical insufficiency:

• Adrenal vein sampling (AVS) in primary aldosteronism

• Therapeutic use: Synacthen Depot


Contraindications :

Hypersensitivity to cosyntropin or any component of the formulation, Treatment of asthma or other allergic conditions (increased risk of anaphylactic reactions); use in premature babies and neonates <1 month; acute psychosis; untreated bacterial, fungal, and viral infections; active or latent peptic ulcer; refractory heart failure; Cushing syndrome; treatment of primary adrenocortical insufficiency; adrenogenital syndrome.


Dosing :

Screening of adrenocortical insufficiency: IM, IV

≤2 years of age: 0.125 mg.

>2 years of age: 0.25 mg.

Therapeutic use: Synacthen Depot:

3 to 6 years: Initial: 0.25 to 0.5 mg daily; maintenance: 0.25 to 0.5 mg every 2 to 8 days

7 to 15 years: Initial: 0.25 to 1 mg daily; maintenance: 0.25 to 1 mg every 2 to 8 days

≥16 years of age: Initial for acute treatment: 1 mg daily for 3 days; maintenance dose is individualized: 0.5 to 1 mg every 2 to 3 days or twice weekly or 2 mg once weekly or less frequently.


Adverse Effect :

Bradycardia, hypertension, peripheral edema, tachycardia, Skin rash, urticaria at injection site, Anaphylaxis, hypersensitivity reaction, Adrenal hemorrhage (Synacthen Depot).


Interaction :

Clonazepam, Diazepam, Nitrazepam: Cosyntropin may enhance the hepatotoxic effect.
Phenobarbital, Phenytoin, Primidone, Valproate: Cosyntropin may enhance the hepatotoxic effect.


07/14/2019 19:41:36 Cosyntropin
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