Anti-Rh

D Immunoglobulin, Human Anti-D Immunoglobulin

Mechanism :

Immune Globulin sterile solutions containing IgG anti-D (anti-Rh) for use in preventing Rh immunization. They are manufactured from human plasma containing anti-D. A single dose contains sufficient anti-D (approximately 300 µg) to suppress the immune response to 15 mL (or less) of Rh-positive red blood cells. The mechanism of action is unknown. Not effective in altering the course or consequences of Rh immunization once it has occurred.

Indication :

• Use after Rh Incompatible Transfusion.
• Rh negative females when they are pregnant with a Rh positive fetus.

Contraindications :

Individuals known to have had an anaphylactic or severe systemic reaction to human globulin should not receive any Rh(D) Immune Globulin (Human).

Dosing :

For prevention of hemolytic disease in newborn:

Antepartum administration: 1500 IU or 300 mcg IV/IM at 28-30 weeks of gestation.

Postpartum: 1500 IU IV/IM within 72 hours (can be given upto 28 days).

Chronic immune thrombocytopenic purpura:

250 IU/kg IV. Infuse IV over 3-5 min.

Incompatible transfusions:

In the event of exposure to Rh (D) positive whole blood: 9-12 mcg (45-60 IU)/mL blood IM.

Adverse Effect :

Swelling, induration, redness and mild pain at the site of injection.

Interaction :

No specific drug interactions reported.

Hepatic Dose :