Drug Index

Daptomycin

 
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Mechanism :

Daptomycin binds to components of the cell membrane of susceptible organisms and causes rapid depolarization, inhibiting intracellular synthesis of DNA, RNA, and protein. Daptomycin is bactericidal in a concentration-dependent manner.


Indication :

• Treatment of complicated skin and skin structure infections

• S. aureus bacteraemia including those with right-sided infective endocarditis

• Cerebrospinal fluid shunt infection

• Diabetic foot infections

• Meningitis

• Osteomyelitis and/or septic arthritis


Contraindications :

Hypersensitivity to daptomycin or any component of the formulation.


Dosing :

IV

Skin and skin structure infections:Duration of therapy: ≤14 days.

1 to <2 years: 10 mg/kg once daily.

2 to 6 years: 9 mg/kg once daily.

7 to 11 years: 7 mg/kg once daily.

12 to 17 years: 5 mg/kg once daily.

≥18 years: 4 mg/kg once daily.

S. aureus bacteremia: Duration of therapy: ≤42 days.

1 to 6 years: 12 mg/kg once daily.

7 to 11 years: 9 mg/kg once daily.

12 to 17 years: 7 mg/kg once daily.

≥18 years: 6 mg/kg once daily.


Adverse Effect :

Chest pain, hypertension, hypotension, insomnia, headache, dizziness, pruritus, diaphoresis, diarrhea, abdominal pain, UTI, abnormal hepatic function tests, gram-negative organism infection, bacteremia, increased creatine phosphokinase.


Interaction :

HMG-CoA Reductase Inhibitors (Statins): May enhance the adverse/toxic effect of Daptomycin. Specifically, the risk of skeletal muscle toxicity may be increased.


07/19/2019 04:13:03 Daptomycin
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