Drug Index

Mechanism :

Daptomycin binds to components of the cell membrane of susceptible organisms and causes rapid depolarization, inhibiting intracellular synthesis of DNA, RNA, and protein. Daptomycin is bactericidal in a concentration-dependent manner.


Indication :

  • Treatment of complicated skin and skin structure infections
  • S. aureus bacteraemia including those with right-sided infective endocarditis
  • Cerebrospinal fluid shunt infection
  • Diabetic foot infections
  • Meningitis
  • Osteomyelitis and/or septic arthritis

Contraindications :

Hypersensitivity to daptomycin or any component of the formulation.


Dosing :

IV
Skin and skin structure infections:
Duration of therapy:
≤14 days.
1 to <2 years: 10 mg/kg once daily.
2 to 6 years: 9 mg/kg once daily.
7 to 11 years: 7 mg/kg once daily.
12 to 17 years: 5 mg/kg once daily.
≥18 years: 4 mg/kg once daily.
S. aureus bacteremia:
Duration of therapy:
≤42 days.
1 to 6 years: 12 mg/kg once daily.
7 to 11 years: 9 mg/kg once daily.
12 to 17 years: 7 mg/kg once daily.
≥18 years: 6 mg/kg once daily.

Adverse Effect :

Chest pain, hypertension, hypotension, insomnia, headache, dizziness, pruritus, diaphoresis, diarrhea, abdominal pain, UTI, abnormal hepatic function tests, gram-negative organism infection, bacteremia, increased creatine phosphokinase.


Interaction :

HMG-CoA Reductase Inhibitors (Statins): May enhance the adverse/toxic effect of Daptomycin. Specifically, the risk of skeletal muscle toxicity may be increased.



Renal Dose :

Dose in Renal Impairment GFR (mL/min)
30-50Dose as in normal renal function
<304 mg/kg every 48 hours

Dose in Patients undergoing Renal Replacement Therapies
CAPDNot dialysed. Dose as in GFR<30 mL/min
HDNot dialysed. Dose as in GFR<30 mL/min
HDF/High fluxDialysed. Dose as in GFR<30 mL/ min
CAV/VVHD/VVHDFSlightly dialysed. 4–6 mg/kg every 48 hours

Hepatic Dose :

No dosage adjustments are recommended.
09/28/2020 08:44:02 Daptomycin
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