Drug Index


Mechanism :

Two molecules of deferasirox are capable of binding to 1 atom of iron. Deferasirox works in treating iron toxicity by binding trivalent (ferric) iron (for which it has a strong affinity), forming a stable complex which is eliminated via the kidneys.

Indication :

  • Transfusional Hemosiderosis
  • Non-transfusion-dependent thalassemia

Contraindications :

Hypersensitivity, Renal OR liver failure, Thrombocytopenia.

Dosing :

Transfusional iron overload:
2 years of age or older:
Initial dose: 20 mg/kg once a day.
Maintenance dose: 20 to 40 mg/kg/day.
Maximum dose: 40 mg/kg/day.
10 mg/kg orally once daily.

Adverse Effect :

Renal toxicity, proteinuria, hepatic toxicity, GI hemorrhage, bone marrow suppression, hypersensitivity, auditory and ocular abnormalities.

Interaction :

Aluminium: Possible physicochemical interaction.
Anticoagulants: Increase the risk for gastrointestinal ulceration/irritation and/or GI bleeding. If these two agents must be used, patients need to be closely monitored for signs and symptoms of GI toxicity.
Etravirine, Tofacitinib (and other CYP3A4 substrates): When administered concomitantly with deferasirox, may experience a decrease in serum concentration. It is recommended to monitor therapy.

Renal Dose :

Dose in Renal Impairment GFR (mL/min)

Dose in Patients undergoing Renal Replacement Therapies
CAPDUnlikely to be dialysed. Avoid
HDDialysed. Avoid
HDF/High fluxDialysed. Avoid
CAV/VVHDUnlikely to be dialysed. Avoid

Hepatic Dose :

Child-Pugh A: No dosage adjustment necessary.
Child-Pugh B: Reduce the starting dose by 50%.
Child-Pugh C: Avoid use.
02/14/2024 21:35:44 Deferasirox
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