Drug Index

Deferasirox

 
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Mechanism :

Two molecules of deferasirox are capable of binding to 1 atom of iron. Deferasirox works in treating iron toxicity by binding trivalent (ferric) iron (for which it has a strong affinity), forming a stable complex which is eliminated via the kidneys.


Indication :

• Transfusional Hemosiderosis

• Non-transfusion-dependent thalassemia


Contraindications :

Hypersensitivity, Renal OR liver failure, Thrombocytopenia.


Dosing :

Oral

Transfusional iron overload:

2 years of age or older: Initial dose: 20 mg/kg once a day. Maintenance dose: 20 to 40 mg/kg/day. Maximum dose: 40 mg/kg/day.

Thalassemia:

10 mg/kg orally once daily.


Adverse Effect :

Renal toxicity, proteinuria, hepatic toxicity, GI hemorrhage, bone marrow suppression, hypersensitivity, auditory and ocular abnormalities.


Interaction :

Aluminium: Possible physicochemical interaction.
Anticoagulants: Increase the risk for gastrointestinal ulceration/irritation and/or GI bleeding. If these two agents must be used, patients need to be closely monitored for signs and symptoms of GI toxicity.
Etravirine, Tofacitinib (and other CYP3A4 substrates): When administered concomitantly with deferasirox, may experience a decrease in serum concentration. It is recommended to monitor therapy.


07/18/2019 01:59:42 Deferasirox
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