Drug Index


Mechanism :

Deferiprone is an oral drug that chelates iron and is used to treat thalassaemia major.

Indication :

  • Iron overload
  • Hemolytic anemia on multiple transfusion
  • Thalassemia major

Contraindications :

Contraindicated if there is a history of agranulocytosis or recurrent episodes of neutropenia.

Dosing :

>6 years:
25 mg/kg/dose or 250 mg dose 3 times daily. Max: 100 mg/kg/day.

Adverse Effect :

Nausea, vomiting, altered taste, abdominal pain, increased appetite, reddish/brown urine, joint pain, agranulocytosis, neutropenia, arthropathy.

Interaction :

Neutropenic Drugs: Patients should not take any other neutropenic drugs.

Renal Dose :

Dose in Renal Impairment GFR (mL/min)
20-50Dose as in normal renal function
10-20Give 50% of dose and monitor
<10Give 50% of dose and monitor

Dose in Patients undergoing Renal Replacement Therapies
CAPDUnknown dialysability. Dose as in GFR<10 mL/min
HDDialysed. Dose as in GFR<10 mL/min
HDF/High fluxDialysed. Dose as in GFR<10 mL/min
CAV/VVHDDialysed. Dose as in GFR=10–20 mL/min

Hepatic Dose :

No dosage adjustments are recommended. Data for use in severe hepatic impairment is lacking.
12/24/2023 08:18:11 Deferiprone
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