Drug Index


Mechanism :

desflurane enhances inhibitory postsynaptic channel activity and inhibits excitatory synaptic activity resulting in general anesthesia.

Indication :

  • Anesthesia

Contraindications :

Hypersensitivity to desflurane, other halogenated agents, or any component of the formulation; known or suspected genetic susceptibility to malignant hyperthermia; patients in whom general anesthesia is contraindicated; induction of anesthesia in pediatric patients; history of moderate to severe hepatic impairment following anesthesia with desflurane or other halogenated agents and not otherwise explained.

Dosing :

Inhaled concentrations of 5.2% to 10% with or without nitrous oxide.

Adverse Effect :

Nausea, vomiting, cough, breath holding, apnea, decreased oxygen saturations, bradycardia, hypertension, arrhythmia, sialorrhea, laryngospasm.

Interaction :

Blood Pressure Lowering Agents: May enhance the hypotensive effect of Hypotension-Associated Agents.
CNS Depressants: May enhance the adverse/toxic effect of other CNS Depressants.
Epinephrine (Systemic): Inhalational Anesthetics may enhance the arrhythmogenic effect of epinephrine.

Hepatic Dose :

No dosage adjustments are recommended.
01/18/2024 18:07:17 Desflurane
Disclaimer: The information given by www.pediatriconcall.com is provided by medical and paramedical & Health providers voluntarily for display & is meant only for informational purpose. The site does not guarantee the accuracy or authenticity of the information. Use of any information is solely at the user's own risk. The appearance of advertisement or product information in the various section in the website does not constitute an endorsement or approval by Pediatric Oncall of the quality or value of the said product or of claims made by its manufacturer.
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0