Drug Index

Desflurane

 
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Mechanism :

desflurane enhances inhibitory postsynaptic channel activity and inhibits excitatory synaptic activity resulting in general anesthesia.


Indication :

• Anesthesia


Contraindications :

Hypersensitivity to desflurane, other halogenated agents, or any component of the formulation; known or suspected genetic susceptibility to malignant hyperthermia; patients in whom general anesthesia is contraindicated; induction of anesthesia in pediatric patients; history of moderate to severe hepatic impairment following anesthesia with desflurane or other halogenated agents and not otherwise explained.


Dosing :

Inhaled concentrations of 5.2% to 10% with or without nitrous oxide.


Adverse Effect :

Nausea, vomiting, cough, breath holding, apnea, decreased oxygen saturations, bradycardia, hypertension, arrhythmia, sialorrhea, laryngospasm.


Interaction :

Blood Pressure Lowering Agents: May enhance the hypotensive effect of Hypotension-Associated Agents.
CNS Depressants: May enhance the adverse/toxic effect of other CNS Depressants.
Epinephrine (Systemic): Inhalational Anesthetics may enhance the arrhythmogenic effect of epinephrine.


07/14/2019 06:44:43 Desflurane
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