Drug Index

Dexlansoprazole

 
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Mechanism :

Proton pump inhibitor; decreases acid secretion in gastric parietal cells through inhibition of (H+, K+)-ATPase enzyme system.


Indication :

• GERD

• Erosive esophagitis


Contraindications :

Known hypersensitivity to dexlansoprazole or any component of the formulation; concomitant use with products that contain rilpivirine.


Dosing :

≥12 years of age.

GERD: 30 mg once daily for 4 weeks orally.

Erosive esophagitis: Healing: 60 mg once daily for up to 8 weeks, Maintenance: 30 mg orally once daily for upto 16 weeks.


Adverse Effect :

Abdominal pain, diarrhea, flatulence, abdominal distress and tenderness, Barrett esophagus, angina pectoris, bradycardia, arrhythmias, chest pain, DVT, hypertension, headache, dizziness, falling, psychomotor agitation, anemia, thrombocytopenia, abnormal hepatic functions tests.


Interaction :

Clopidogrel: Dexlansoprazole may decrease serum concentrations of the active metabolite(s) of Clopidogrel.
Dasatinib: Proton Pump Inhibitors may decrease the serum concentration of Dasatinib.
Iron Salts: Proton Pump Inhibitors may decrease the absorption of Iron Salts.
Methotrexate: Proton Pump Inhibitors may increase the serum concentration of Methotrexate.
Voriconazole: May increase the serum concentration of Proton Pump Inhibitors. Proton Pump Inhibitors may increase the serum concentration of Voriconazole.


07/19/2019 03:13:47 Dexlansoprazole
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