Drug Index

Mechanism :

Dipyridamole is a platelet adhesion inhibitor, although the mechanism of action is not fully understood. The mechanism may relate to inhibition of red blood cell uptake of adenosine, itself an inhibitor of platelet reactivity, phosphodiesterase inhibition leading to increased cyclic-3,5-adenosine monophosphate within platelets, and inhibition of thromboxane A2 formation which is a potent stimulator of platelet activation.

Indication :

  • Anti-platelet agent

Contraindications :

Hypersensitivity to dipyridamole and any of the other components.

Dosing :

3-6 mg/kg/day in 3-4 divided doses, orally.

Adverse Effect :

Nausea, diarrhea, throbbing headache, hot flushes, hypotension, dizziness, myalgia, chest pain, abnormal ECG, dizziness.

Interaction :

Adenosine: Dipyridamole has been reported to increase the plasma levels and cardiovascular effects of adenosine.
Cholinesterase Inhibitors: Dipyridamole may counteract the anticholinesterase effect of cholinesterase inhibitors, thereby potentially aggravating myasthenia gravis.
Anticoagulants: Mild bleeding can sometimes occur if anticoagulants and dipyridamole are used concurrently, without altering prothrombin time.

Renal Dose :

Dose in Renal Impairment GFR (mL/min)
20-50Dose as in normal renal function
10-20Dose as in normal renal function
<10Dose as in normal renal function

Dose in Patients undergoing Renal Replacement Therapies
CAPDNot dialysed. Dose as in normal renal function
HDNot dialysed. Dose as in normal renal function
HDF/High fluxNot dialysed. Dose as in normal renal function
CAV/VVHDNot dialysed. Dose as in normal renal function

Hepatic Dose :

Dipyridamole is primarily eliminated via hepatic metabolism.
Mild to moderate hepatic impairment: No dose adjustment required.
Severe hepatic impairment: Dosing has not been studied. Use with caution.
09/28/2020 08:16:37 Dipyridamole
Disclaimer: The information given by www.pediatriconcall.com is provided by medical and paramedical & Health providers voluntarily for display & is meant only for informational purpose. The site does not guarantee the accuracy or authenticity of the information. Use of any information is solely at the user's own risk. The appearance of advertisement or product information in the various section in the website does not constitute an endorsement or approval by Pediatric Oncall of the quality or value of the said product or of claims made by its manufacturer.
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0