Drug Index

Dipyridamole

 
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Mechanism :

Dipyridamole is a platelet adhesion inhibitor, although the mechanism of action is not fully understood. The mechanism may relate to inhibition of red blood cell uptake of adenosine, itself an inhibitor of platelet reactivity, phosphodiesterase inhibition leading to increased cyclic-3,5-adenosine monophosphate within platelets, and inhibition of thromboxane A2 formation which is a potent stimulator of platelet activation.


Indication :

• Anti-platelet agent


Contraindications :

Hypersensitivity to dipyridamole and any of the other components.


Dosing :

3-6 mg/kg/day in 3-4 divided doses, orally.


Adverse Effect :

Nausea, diarrhea, throbbing headache, hot flushes, hypotension, dizziness, myalgia, chest pain, abnormal ECG, dizziness.


Interaction :

Adenosine: Dipyridamole has been reported to increase the plasma levels and cardiovascular effects of adenosine.
Cholinesterase Inhibitors: Dipyridamole may counteract the anticholinesterase effect of cholinesterase inhibitors, thereby potentially aggravating myasthenia gravis.
Anticoagulants: Mild bleeding can sometimes occur if anticoagulants and dipyridamole are used concurrently, without altering prothrombin time.


07/18/2019 12:27:57 Dipyridamole
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