Drug Index

Chlorthalidone

 
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Mechanism :

It is a long acting diuretic agent related to the thiazide group of drugs. It increases the elimination of water and sodium in urine, thus reducing the fluid volume and body sodium. It is used in the treatment of edema, pulmonary edema associated with heart failure and also used to decrease the blood pressure.


Indication :

• Hypertension


Contraindications :

Documented hypersensitivity to chlorthalidone or sulfonamides.

Anuria.


Dosing :

Initially 0.3 mg/kg/day (Oral); may increase to 2 mg/kg/day; maximum: 50 mg/day.


Adverse Effect :

GI disturbances, hearing loss, hypochloremic alkalosis, vasculitis, spasticity, restlessness, impotency, volume depletion and hypokalemia.


Interaction :

Amisulpride: Risk of hypokalemia.
Cisapride: Risk of prolonged QT interval.
Isocarboxazid: Hypotensive effect nay be seen.
Tretinoin: Increased photoxicity.



Renal Dose :

Dose in Renal Impairment GFR (mL/min)
30-50Dose as in normal renal function
<30Avoid.

Dose in Patients undergoing Renal Replacement Therapies
CAPDUnlikely to be dialysed. Avoid
HDNot dialysed. Avoid
HDF/High fluxUnknown dialysability. Avoid
CAV/VVHDUnknown dialysability. Dose as in normal renal function

Hepatic Dose :

No dosage adjustments are recommended. Use with caution since minor alterations of fluid and electrolyte balance may precipitate hepatic coma.
04/12/2020 17:51:10 Chlorthalidone
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