Drug Index

Dobutamine

 
print

Mechanism :

Dobutamine is a direct-acting inotropic agent whose primary activity results from stimulation of the b-receptors of the heart while producing comparatively mild chronotropic, hypertensive, arrhythmogenic, and vasodilative effects. It does not cause the release of endogenous norepinephrine, as does dopamine.


Indication :

• Cardiac failure

• Cardiac surgery

• Septicemia

• Myocardial stress testing


Contraindications :

Dobutamine is contraindicated in patients with idiopathic hypertrophic subaortic stenosis and in patients who have shown previous manifestations of hypersensitivity to dobutamine.


Dosing :

Continuous IV infusion: 2-10 microgram/kg/min increased to a max of 20 microgram/kg/min in newborn and 40 microgram/kg/min in older children if necessary.

Suggested drip administration: 6 x wt (kg) x desired dose (mcg/kg/min)/desired fluid rate (Ml/hr) = mg of dobutamine per 100 ml solution.


Adverse Effect :

Chest pain, tachycardia, angina, ectopic beats, palpitation, hypertension, nausea, vomiting, tingling sensation, paraesthesia, dyspnea, headache, hypersensitivity (rash, fever, bronchospasm), hypokalemia.


Interaction :

Nitroprusside: Concomitant use of dobutamine and nitroprusside results in a higher cardiac output and, a lower pulmonary wedge pressure than when either drug is used alone.


07/18/2019 01:51:47 Dobutamine
ask a doctor
Ask a Doctor
Disclaimer: The information given by www.pediatriconcall.com is provided by medical and paramedical & Health providers voluntarily for display & is meant only for informational purpose. The site does not guarantee the accuracy or authenticity of the information. Use of any information is solely at the user's own risk. The appearance of advertisement or product information in the various section in the website does not constitute an endorsement or approval by Pediatric Oncall of the quality or value of the said product or of claims made by its manufacturer.
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0