Drug Index

Dolasetron

 
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Indication :

• Prevention of cancer chemotherapy induced vomiting and post-operative vomiting


Dosing :

<2 years: Safety not established

2-16 years: 1.8 mg/kg orally 1 hour before chemotherapy. 0.35 mg/kg IV 15 mins before cessation of anesthesia for prevention of post-operative vomiting.

Max dose: 100 mg/dose orally, 12.5 mg/dose IV.


Adverse Effect :

Headache, diarrhea, dizziness, brady-tachycardia, hypo-hypertension, fever, urinary retention, itching.


Renal Dose :

Dose in Renal Impairment GFR (mL/min)
20-50Dose as in normal renal function
10-20Dose as in normal renal function
<10Dose as in normal renal function

Dose in Patients undergoing Renal Replacement Therapies
CAPDUnlikely to be dialysed. Dose as in normal renal function
HDUnlikely to be dialysed. Dose as in normal renal function
HDF/High fluxUnlikely to be dialysed. Dose as in normal renal function
CAV/VVHDUnlikely to be dialysed. Dose as in normal renal function

Hepatic Dose :

No dosage adjustments are recommended.
05/24/2020 22:40:46 Dolasetron
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