Drug Index

Dupilumab

Mechanism :

Dupilumab is a human monoclonal IgG4 antibody that inhibits interleukin-4 (IL-4) and interleukin-13 (IL-13) signalling by binding to the IL-4Ra subunit.


Indication :

  • Off-Label: Asthma, moderate to severe (uncontrolled)
  • Atopic dermatitis: Treatment of moderate to severe atopic dermatitis in adults

Contraindications :

Known hypersensitivity to dupilumab or any component of the formulation.


Dosing :

In patients aged ≥12 years with eosinophilic phenotype or PO corticosteroid dependent asthma.
400 mg SC once, then 200 mg once in 2 weeks.
Atopic dermatitis:
Adults
600 mg (i.e. two 300 mg injections) SC once, and then 300 mg SC every other week.

Adverse Effect :

Herpes simplex infection, Oral herpes, antibody development, injection site reaction, conjunctivitis.


Interaction :

Belimumab: Monoclonal Antibodies may enhance the adverse/toxic effect of Belimumab.
Vaccines (Live): Dupilumab may enhance the adverse/toxic effect of Vaccines.



Hepatic Dose :

No dosage adjustments are recommended.
12/17/2020 02:37:27 Dupilumab
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