Drug Index

Bezafibrate

 
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Mechanism :

Bezafibrate is a lipid lowering drug.


Indication :

• Hypercholesterolemia

• Dyslipidemia


Contraindications :

Renal and hepatic dysfunction, and gall bladder disease.


Dosing :

Oral: 200 mg/day in adolescents. Very limited use in children.


Adverse Effect :

Gastrointestinal, nausea, anorexia, gastric pain; headache, pruritus, urticaria, myopathy.


Interaction :

Warfarin: Enhanced effect.
HMG-COA Reductase Inhibitors: Increased risk of rhabdomyolysis.
Bile Acid Sequestrants: Elevation in liver enzymes.



Renal Dose :

Dose in Renal Impairment GFR (mL/min)
40-60400 mg daily
15-40200 mg every 24–48 hours
<15Avoid

Dose in Patients undergoing Renal Replacement Therapies
CAPDNot dialysed. 200 mg every 72 hours
HDNot dialysed. 200 mg every 72 hours
HDF/High fluxUnknown dialysability. 200 mg every 72 hours
CAV/VVHDUnknown dialysability. Dose as in GFR=15–40 mL/min

Hepatic Dose :

Avoid use in severe hepatic impairment.
04/12/2020 18:54:30 Bezafibrate
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