Drug Index

Eflornithine

 
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Mechanism :

Cream: Eflornithine inhibits the enzyme ornithine decarboxylase (ODC) which inhibits cell division and synthetic functions and thereby affects the rate of hair growth.


Indication :

• Facial hair reduction: Reduce unwanted hair in females from the face and adjacent areas under the chin.

• Off-Label: Meningoencephalitic stage of Trypanosoma brucei gambiense infection (sleeping sickness)


Contraindications :

Hypersensitivity to eflornithine or any component of the formulation.


Dosing :

Available as IV injection and 13.9% cream.

Facial hair reduction (females):

Children ≥12 years and Adolescents: Apply thin layer of cream to affected areas of face and areas under the chin twice daily, at least 8 hours apart.

Treatment of infections caused by Trypanosoma brucei gambiense infection (sleeping sickness) (off-label use):

IV infusion: 100 mg/kg/dose given every 6 hours for 14 days.


Adverse Effect :

Acne vulgaris, pseudo folliculitis barbae, Headache, tingling of skin, dizziness, stinging of the skin, burning sensation of skin, pruritus, skin rash, xeroderma, erythema, alopecia.


Interaction :

No known significant interactions.


08/11/2019 20:56:08 Eflornithine
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