Drug Index

Epoprostrenol

 
print
Synonym :

Prostacyclin

Mechanism :

Epoprostenol (prostacyclin), a metabolite of arachidonic acid, is a naturally occurring prostaglandin with potent vasodilatory activity and inhibitory activity of platelet aggregation. Epoprostenol has two major actions, direct vasodilation of pulmonary and systemic arterial vascular beds, and inhibition of platelet aggregation.

Indication :

• Pulmonary hypertension


Contraindications :

Chronic use is contraindicated in patients with CHF due to severe left ventricular systolic dysfunction. Some patients with pulmonary hypertension have developed pulmonary edema during dose initiation, which may be associated with pulmonary veno-occlusive disease. Also contraindicated in patients with known hypersensitivity to the drug or to structurally-related compounds.


Dosing :

Start with 2 ng/kg/min as an intravenous infusion over 1-2 days. Adjust dose by 1-2 ng/kg/min every 15 minutes or longer until desired effect is seen or maximum dose is reached.


Adverse Effect :

Nausea, vomiting, headache, hypotension, flushing, anxiety, chest pain, bradycardia, dyspnea, dizziness, musculoskeletal pain, abdominal pain, tachycardia. Chronic use has led to right ventricular failure, and pallor.


Interaction :

Diuretics, antihypertensive agents, or other vasodilators: Additional reductions in blood pressure Antiplatelet agents or anticoagulants: increase the risk of bleeding
07/17/2019 20:42:55 Epoprostrenol
ask a doctor
Ask a Doctor
Disclaimer: The information given by www.pediatriconcall.com is provided by medical and paramedical & Health providers voluntarily for display & is meant only for informational purpose. The site does not guarantee the accuracy or authenticity of the information. Use of any information is solely at the user's own risk. The appearance of advertisement or product information in the various section in the website does not constitute an endorsement or approval by Pediatric Oncall of the quality or value of the said product or of claims made by its manufacturer.
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0