Drug Index

Epoprostrenol

 
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Synonym :

Prostacyclin

Mechanism :

Epoprostenol (prostacyclin), a metabolite of arachidonic acid, is a naturally occurring prostaglandin with potent vasodilatory activity and inhibitory activity of platelet aggregation. Epoprostenol has two major actions, direct vasodilation of pulmonary and systemic arterial vascular beds, and inhibition of platelet aggregation.

Indication :

• Pulmonary hypertension


Contraindications :

Chronic use is contraindicated in patients with CHF due to severe left ventricular systolic dysfunction. Some patients with pulmonary hypertension have developed pulmonary edema during dose initiation, which may be associated with pulmonary veno-occlusive disease. Also contraindicated in patients with known hypersensitivity to the drug or to structurally-related compounds.


Dosing :

Start with 2 ng/kg/min as an intravenous infusion over 1-2 days. Adjust dose by 1-2 ng/kg/min every 15 minutes or longer until desired effect is seen or maximum dose is reached.


Adverse Effect :

Nausea, vomiting, headache, hypotension, flushing, anxiety, chest pain, bradycardia, dyspnea, dizziness, musculoskeletal pain, abdominal pain, tachycardia. Chronic use has led to right ventricular failure, and pallor.


Interaction :

Diuretics, antihypertensive agents, or other vasodilators: Additional reductions in blood pressure Antiplatelet agents or anticoagulants: increase the risk of bleeding

Renal Dose :

Dose in Renal Impairment GFR (mL/min)
20-50Dose as in normal renal function
10-20Dose as in normal renal function
<10Dose as in normal renal function

Dose in Patients undergoing Renal Replacement Therapies
CAPDUnknown dialysability. Dose as in normal renal function
HDUnknown dialysability. Dose as in normal renal function
HDF/High fluxUnknown dialysability. Dose as in normal renal function
CAV/VVHDUnknown dialysability. Dose as in normal renal function

Hepatic Dose :

No dosage adjustments are recommended.
06/24/2020 06:19:56 Epoprostrenol
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