Drug Index

Ertapenem

 
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Mechanism :

The bactericidal activity of ertapenem results from the inhibition of cell wall synthesis and is mediated through ertapenem binding to penicillin binding proteins (PBPs). In Escherichia coli, it has strong affinity toward PBPs 1a, 1b, 2, 3, 4 and 5 with preference for PBPs 2 and 3. Ertapenem is stable against hydrolysis by a variety of beta-lactamases, including penicillinases, and cephalosporinases and extended spectrum beta-lactamases. Ertapenem is hydrolysed by metallo-beta-lactamases.


Indication :

• Complicated skin and soft tissue infections

• Complicated intra-abdominal infections

• Complicated pneumonia

• Complicated urinary tract infections


Contraindications :

Hypersensitivity to ertapenem, beta-lactams, or other drugs in this class.


Dosing :

Under 3 months: Safety and efficacy not established.

3 months-12 years: 15 mg/kg either IV/IM twice daily for 14 days; Max: 1 g twice daily.

>12 years: 1 g/day IV/IM for 14 days.


Adverse Effect :

Hypersensitivity to ertapenem, beta-lactams, or other drugs in this class.

Diarrhea, elevated liver function tests, pruritus, tachycardia, constipation, insomnia, increased alkaline phosphatase, dyspepsia, altered mental status, fever, abdominal pain, vomiting, edema, drug rash with eosinophilia, DRESS syndrome, hypotension, headache, chest pain, increased platelet count, acid regurgitation, fatigue.

07/19/2019 03:14:58 Ertapenem
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