Drug Index

Etravirine

 
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Mechanism :

As a non-nucleoside reverse transcriptase inhibitor, etravirine has activity against HIV-1 by binding to reverse transcriptase.


Indication :

• HIV-1 infection with documented non-nucleoside reverse transcriptase inhibitor (NNRTI) resistance


Contraindications :

Hypersensitivity to etravirine or any component of the formulation; concomitant use with the hepatitis C combination regimen of ombitasvir, paritaprevir, ritonavir and with drugs containing dasabuvir.


Dosing :

Oral:

Children 2 to <18 years of age:

≥10 kg to <20 kg: 100 mg twice daily.

≥20 kg to <25 kg: 125 mg twice daily.

≥25 kg to <30 kg: 150 mg twice daily.

≥30 kg: 200 mg twice daily.


Adverse Effect :

Rash, nausea, increased LDL, GI disorders, fatigue, peripheral neuropathy, increased creatinine, diarrhea, Stevens-Johnson syndrome, erythema multiforme, angina, angioedema, TEN.


Interaction :

CYP2C19 Inducers: May increase the metabolism of CYP2C19 Substrates.
CYP3A4 Inducers: May increase the metabolism of CYP3A4 Substrates.
CYP3A4 Substrates: CYP3A4 Inducers may decrease the serum concentration of CYP3A4 Substrates.
Efavirenz: Reverse Transcriptase Inhibitors (Non-Nucleoside) may increase the serum concentration of Efavirenz.
HMG-CoA Reductase Inhibitors (Statins): Etravirine may decrease the serum concentration of HMG-CoA Reductase Inhibitors (Statins).
Phosphodiesterase 5 Inhibitors: Etravirine may decrease the serum concentration of Phosphodiesterase 5 Inhibitors.
Protease Inhibitors: May decrease the serum concentration of Etravirine. This effect is anticipated with darunavir, saquinavir, and lopinavir (with low-dose ritonavir).


07/19/2019 03:04:19 Etravirine
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