Drug Index

Evolocumab

 
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Mechanism :

Evolocumab is a human monoclonal antibody (IgG2 isotype) that binds to proprotein convertase subtilisin kexin type 9 (PCSK9). PCSK9 binds to the low-density lipoprotein receptors (LDLR) on hepatocyte surfaces to promote LDLR degradation within the liver.


Indication :

• Homozygous familial hypercholesterolemia

• Primary hyperlipidemia (including heterozygous familial hyperlipidemia)


Contraindications :

Serious hypersensitivity to evolocumab or any component of the formulation.


Dosing :

Adolescents 13 to 17 years:

Homozygous familial hypercholesterolemia:

SC 420 mg once monthly.

Primary Hyperlipidemia:

SC 140 mg every 2 weeks or 420 mg once monthly.

Note: Use in combination with diet and other lipid-lowering therapies.


Adverse Effect :

Nasopharyngitis, hypertension, dizziness, fatigue, skin rash, gastroenteritis, UTI, influenza, injection site reaction, myalgia.


Interaction :

Belimumab: Monoclonal Antibodies may enhance the adverse/toxic effect of Belimumab.


07/14/2019 19:27:56 Evolocumab
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