Drug Index

Famotidine

 
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Mechanism :

Famotidine is a competitive inhibitor of histamine H2-receptors. The primary clinically important pharmacologic activity is inhibition of gastric juice secretion. Famotidine reduces the acid and pepsin content, as well as the volume, of basal, nocturnal, and stimulated gastric secretion.


Indication :

• Peptic ulcer

• GERD

• Heartburn


Contraindications :

Hypersensitivity to any component of this medication.


Dosing :

Peptic Ulcer Disease:

1-16 years: 0.5 mg/kg/day once orally at bed time OR 0.25 mg/kg IV every 12 hours; Max: 40 mg/day.

GERD:

Under 3 months: 0.5 mg/kg/day orally once daily upto 8 weeks.

3-12 months: 1 mg/kg/day orally every 12 hours for upto 8 weeks.

1-16 years: 1 mg/kg/day orally in two divided doses; Max: 40 mg/day.

Heartburn:

Under 12 years: Not established.

Above 12 years: 10-20 mg twice daily; may take 15-60 min before eating foods that can cause heartburn.


Adverse Effect :

Headache, dizziness, constipation and diarrhea.

Serious Reactions: Anaphylaxis, Stevens-Johnson syndrome, angioedema, leukopenia, toxic epidermal necrolysis, agranulocytosis, thrombocytopenia, pancytopenia, seizures, arrhythmias, AV block, hepatitis, cholestatic jaundice, interstitial pneumonia, QT prolongation.


Interaction :

Ketoconazole, Triamterene, Delavirdine, Itraconazole, Cefpodoxime, Cyanocobalamin, Indomethacin, Melphalan: Decreased absorption.
Tolazoline: Decreased effect of Tolazoline.


07/14/2019 19:35:41 Famotidine
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