Drug Index

Felodipine

 
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Mechanism :

Inhibits calcium ions from entering the “slow channels” or select voltage-sensitive areas of vascular smooth muscle and myocardium during depolarization, producing a relaxation of coronary vascular smooth muscle and coronary vasodilation.


Indication :

• Management of hypertension (off-label in children)


Contraindications :

Hypersensitivity to felodipine or other dihydropyridines; women of childbearing potential, in pregnancy, and during lactation.


Dosing :

Children ≥6 years and Adolescents (off-label use): Oral: Initial: 2.5 mg once daily; may increase as needed at no less than 2-week intervals to a maximum of 10 mg once daily


Adverse Effect :

Peripheral edema, headache, flushing, tachycardia.


Interaction :

Alpha1-Blockers: May enhance the hypotensive effect of Calcium Channel Blockers.
Calcium Channel Blockers (Nondihydropyridine): Calcium Channel Blockers (Dihydropyridine) may enhance the hypotensive effect of Calcium Channel Blockers (Nondihydropyridine).
CYP3A4 Inducers: May increase the metabolism of CYP3A4 Substrates.
CYP3A4 Inhibitors: May decrease the metabolism of CYP3A4 Substrates.
Fosphenytoin: Calcium Channel Blockers may increase the serum concentration of Fosphenytoin.
Hypotension-Associated Agents: Blood Pressure Lowering Agents may enhance the hypotensive effect of Hypotension-Associated Agents.
Ketoconazole (Systemic): May increase the serum concentration of Felodipine.
Phenytoin: Calcium Channel Blockers may increase the serum concentration of Phenytoin.


07/14/2019 19:30:20 Felodipine
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