Drug Index

Fenofibrate

 
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Mechanism :

Fenofibrate is a lipid regulating agent available for oral administration. Fenofibric acid, the active metabolite of fenofibrate, produces reductions in total cholesterol, LDL cholesterol, apolipoprotein B, total triglycerides, and VLDL in treated patients. In addition, treatment with fenofibrate results in increases in high density lipoprotein (HDL) and apoproteins apo AI and apo AII. It acts by the activation of peroxisome proliferator activated receptor a.


Indication :

• Hyperlipidemia

• Familial hypercholesterolemia


Contraindications :

Renal and hepatic dysfunction, and gall bladder disease.


Dosing :

One capsule (67 mg) micronized fenofibrate/day/20 kg.


Adverse Effect :

Nausea, anorexia, gastric pain; headache, pruritus, urticaria, myopathy.


Interaction :

Warfarin: Enhanced effect.
HMG-COA reductase inhibitors: Increased risk of rhabdomyolysis.
Bile acid sequestrants: Elevation in liver enzymes.


07/18/2019 12:07:25 Fenofibrate
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