Drug Index


Mechanism :

Inhibits RNA polymerase sigma subunit resulting in inhibition of protein synthesis and cell death in susceptible organisms including C. difficile.

Indication :

  • Treatment of Clostridium difficile infection.

Contraindications :

Hypersensitivity to fidaxomicin.

Dosing :

<18 years:
Safety and efficacy not established.
Oral: 200 mg twice daily for 10 days.

Adverse Effect :

Nausea, GIT hemorrhage, abdominal pain, vomiting, anemia, neutropenia.

Interaction :

Lactobacillus and Estriol: Antibiotics may diminish the therapeutic effect of Lactobacillus and Estriol.
Mizolastine: Macrolide Antibiotics may increase the serum concentration of Mizolastine.
Sodium Picosulfate: Antibiotics may diminish the therapeutic effect of Sodium Picosulfate.

Hepatic Dose :

No dosage adjustment is recommended.
02/14/2024 22:01:42 Fidaxomicin
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