Drug Index

Fidaxomicin

 
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Mechanism :

Inhibits RNA polymerase sigma subunit resulting in inhibition of protein synthesis and cell death in susceptible organisms including C. difficile.


Indication :

• Treatment of Clostridium difficile infection.


Contraindications :

Hypersensitivity to fidaxomicin.


Dosing :

<18 years: Safety and efficacy not established.

Adults: Oral: 200 mg twice daily for 10 days.


Adverse Effect :

Nausea, GIT hemorrhage, abdominal pain, vomiting, anemia, neutropenia.


Interaction :

Lactobacillus and Estriol: Antibiotics may diminish the therapeutic effect of Lactobacillus and Estriol.
Mizolastine: Macrolide Antibiotics may increase the serum concentration of Mizolastine.
Sodium Picosulfate: Antibiotics may diminish the therapeutic effect of Sodium Picosulfate.


07/15/2019 06:17:18 Fidaxomicin
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