Drug Index

Gemfibrozil

 
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Synonym :

Lopid

Mechanism :

Gemfibrozil is a lipid regulating agent which decreases serum triglycerides and very low-density lipoprotein (VLDL) cholesterol and increases high density lipoprotein (HDL) cholesterol.


Indication :

• Hyperlipidemia

• Familial hypercholesterolemia

• Neonatal hyperbilirubinemia


Contraindications :

Known hypersensitivity to gemfibrozil, renal and hepatic dysfunction, and gall bladder disease are contraindications for its use.


Dosing :

Limited experience in children (Doses based on clinical trials).

Hyperlipidemia: 150-600 mg twice a day orally.

Neonatal hyperbilirubinemia:60 mg/kg 2 doses for 1 day PO.


Adverse Effect :

Nausea, anorexia, gastric pain, headache, pruritus, urticaria, myopathy, cholestatic jaundice, arrhythmias.


Interaction :

Warfarin: Enhanced effect.
HMG-COA reductase inhibitors: Increased risk of rhabdomyolysis.
Bile acid sequestrants: Elevation in liver enzymes.
Repaglinide and Simvastatin: Cannot be used with Gemfibrozil.



Renal Dose :

Dose in Renal Impairment GFR (mL/min)
20-50Initially 900 mg daily
10-20Initially 900 mg daily. Monitor carefully
<10Initially 900 mg daily. Monitor carefully

Dose in Patients undergoing Renal Replacement Therapies
CAPDNot dialysed. Dose as in GFR<10 mL/min
HDNot dialysed. Dose as in GFR<10 mL/min
HDF/High fluxNot dialysed. Dose as in GFR<10 mL/min
CAV/VVHDNot dialysed. Dose as in GFR=10– 20 mL/min

Hepatic Dose :

Use is contraindicated in hepatic impairment and in primary biliary cirrhosis.
05/25/2020 00:55:33 Gemfibrozil
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