Glucarpidase
Mechanism :
Glucarpidase is a recombinant enzyme which rapidly hydrolyses the carboxyl-terminal glutamate residue from extracellular methotrexate into inactive metabolites (DAMPA and glutamate), resulting in a rapid reduction of methotrexate concentrations independent of renal function.
Indication :
Contraindications :
No contraindications
Dosing :
Methotrexate toxicity:
IV 50 units/kg as a single dose; may require a second dose 24 hours later.
Note: Do not administer
leucovorin calcium within 2 hours before or after glucarpidase.
Adverse Effect :
Antibody development, flushing, hypotension, headache, nausea, paraesthesia.
Interaction :
Leucovorin Calcium-Levoleucovorin: Glucarpidase may decrease serum concentrations of the active metabolite(s) of Leucovorin Calcium-Levoleucovorin.
Hepatic Dose :
No dosage adjustments are needed.