Drug Index

Glucarpidase

 
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Mechanism :

Glucarpidase is a recombinant enzyme which rapidly hydrolyses the carboxyl-terminal glutamate residue from extracellular methotrexate into inactive metabolites (DAMPA and glutamate), resulting in a rapid reduction of methotrexate concentrations independent of renal function.


Indication :

• Methotrexate toxicity


Contraindications :

No contraindications


Dosing :

Methotrexate toxicity: IV 50 units/kg as a single dose; may require a second dose 24 hours later.

Note: Do not administer leucovorin calcium within 2 hours before or after glucarpidase.


Adverse Effect :

Antibody development, flushing, hypotension, headache, nausea, paraesthesia.


Interaction :

Leucovorin Calcium-Levoleucovorin: Glucarpidase may decrease serum concentrations of the active metabolite(s) of Leucovorin Calcium-Levoleucovorin.


07/17/2019 10:40:22 Glucarpidase
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