Drug Index

Mechanism :

Glucarpidase is a recombinant enzyme which rapidly hydrolyses the carboxyl-terminal glutamate residue from extracellular methotrexate into inactive metabolites (DAMPA and glutamate), resulting in a rapid reduction of methotrexate concentrations independent of renal function.


Indication :

  • Methotrexate toxicity

Contraindications :

No contraindications


Dosing :

Methotrexate toxicity:
IV 50 units/kg as a single dose; may require a second dose 24 hours later.
Note: Do not administer leucovorin calcium within 2 hours before or after glucarpidase.

Adverse Effect :

Antibody development, flushing, hypotension, headache, nausea, paraesthesia.


Interaction :

Leucovorin Calcium-Levoleucovorin: Glucarpidase may decrease serum concentrations of the active metabolite(s) of Leucovorin Calcium-Levoleucovorin.



Hepatic Dose :

No dosage adjustments are needed.
09/28/2020 07:36:36 Glucarpidase
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