Drug Index


Mechanism :

Gramicidin is a heterogeneous mixture of six antibiotic compounds divided into three categories: Gramicidin A, Gramicidin B and C, all of which are obtained from the soil bacterial species Bacillus brevis and called collectively Gramicidin D. It is used primarily as a topical antibiotic and is one of the three constituents of consumer antibiotic Neosporin Ophthalmic Solution. Its bactericidal activity is a result of increasing the permeability of the bacterial cell wall allowing inorganic cations to travel through unrestricted, thereby destroying the ion gradient between the cytoplasm and the extracellular environment.

Indication :

  • Bacterial eye infections.

Contraindications :

Fungal and viral infections of the eye.

Dosing :

Available as 1.75 mg/10,000 units/0.025 mg/mL solution.
Apply 1 drop to affected eye.

Adverse Effect :

Burning, irritation, stinging, blurred vision, redness, itching, eyelid swelling or crusting, sensitivity to light.

Interaction :

Use caution with contact lenses. After applying this medication, wait at least 15 minutes before inserting contact lenses.

Hepatic Dose :

No dosage adjustments are recommended.
01/28/2024 16:34:55 Gramicidin
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