Drug Index

Gramicidin

 
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Mechanism :

Gramicidin is a heterogeneous mixture of six antibiotic compounds divided into three categories: Gramicidin A, Gramicidin B and C, all of which are obtained from the soil bacterial species Bacillus brevis and called collectively Gramicidin D. It is used primarily as a topical antibiotic and is one of the three constituents of consumer antibiotic Neosporin Ophthalmic Solution. Its bactericidal activity is a result of increasing the permeability of the bacterial cell wall allowing inorganic cations to travel through unrestricted, thereby destroying the ion gradient between the cytoplasm and the extracellular environment.


Indication :

• Bacterial eye infections.


Contraindications :

Fungal and viral infections of the eye.


Dosing :

Available as 1.75 mg/10,000 units/0.025 mg/mL solution.

Apply 1 drop to affected eye.


Adverse Effect :

Burning, irritation, stinging, blurred vision, redness, itching, eyelid swelling or crusting, sensitivity to light.


Interaction :

Use caution with contact lenses. After applying this medication, wait at least 15 minutes before inserting contact lenses.


07/19/2019 03:20:02 Gramicidin
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