Drug Index

Granisetron

 
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Mechanism :

Granisetron is a selective 5-hydroxytryptamine 3 (5-HT3) receptor antagonist with little or no affinity for other serotonin receptors, including 5-HT1; 5-HT1A; 5-HT1B/C; 5-HT2; for alpha1-, alpha2-, or beta-adrenoreceptors; for dopamine-D2; or for histamine-H1; benzodiazepine; picrotoxin or opioid receptors.


Indication :

• Nausea and vomiting


Contraindications :

Contraindicated in patients with known hypersensitivity to the drug or any of its components.


Dosing :

Under 2 years: Safety and efficacy not established.

2-16 years: 0.01 mg/kg intravenous infusion over 5 minutes or half an hour before chemotherapy.


Adverse Effect :

Headache, diarrhea, asthenia, constipation, drowsiness, sedation, somnolence, abdominal pain and dyspepsia.


Interaction :

Phenytoin, Carbamazepine, and Rifampicin: The clearance of granisetron was significantly increased and ondansetron blood concentrations were decreased.


07/21/2019 22:00:27 Granisetron
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