Drug Index

Granisetron

 
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Mechanism :

Granisetron is a selective 5-hydroxytryptamine 3 (5-HT3) receptor antagonist with little or no affinity for other serotonin receptors, including 5-HT1; 5-HT1A; 5-HT1B/C; 5-HT2; for alpha1-, alpha2-, or beta-adrenoreceptors; for dopamine-D2; or for histamine-H1; benzodiazepine; picrotoxin or opioid receptors.


Indication :

• Nausea and vomiting


Contraindications :

Contraindicated in patients with known hypersensitivity to the drug or any of its components.


Dosing :

Under 2 years: Safety and efficacy not established.

2-16 years: 0.01 mg/kg intravenous infusion over 5 minutes or half an hour before chemotherapy.


Adverse Effect :

Headache, diarrhea, asthenia, constipation, drowsiness, sedation, somnolence, abdominal pain and dyspepsia.


Interaction :

Phenytoin, Carbamazepine, and Rifampicin: The clearance of granisetron was significantly increased and ondansetron blood concentrations were decreased.



Renal Dose :

Dose in Renal Impairment GFR (mL/min)
20-50Dose as in normal renal function
10-20Dose as in normal renal function
<10Dose as in normal renal function

Dose in Patients undergoing Renal Replacement Therapies
CAPDUnknown dialysability. Dose as in normal renal function
HDUnknown dialysability. Dose as in normal renal function. Company recommends timing HD for greater than 2 hours after granisetron dose
HDF/High fluxUnknown dialysability. Dose as in normal renal function. Company recommends timing HD for greater than 2 hours after granisetron dose
CAV/VVHDUnknown dialysability. Dose as in normal renal function

Hepatic Dose :

No dosage adjustments are needed.
05/28/2020 01:36:36 Granisetron
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