Halobetasol Propionate
Mechanism :
Inhibits multiple inflammatory cytokines; produces multiple glucocorticoid and mineralocorticoid effects.
Indication :
- Inflammatory, pruritic & steroid-responsive dermatoses
- Adjunctive treatment in nodular prurigo
- Chronic discoid lupus erythematosus
- Familial benign pemphigus
- Dyshidrosis
- Mycosis fungoides
- Alopecia areata
- Psoriasis
- Seborrheic dermatitis
Contraindications :
Hypersensitivity to drug/class/component.
Caution if skin infection.
Dosing :
0.05% as a cream/ointment/lotion.
<12 years:
Not recommended due to systemic adverse reactions.
>12 years:
Topically used sparingly where required twice daily, maximum dose of 50 g/week. Not to be treated for more than 2 weeks.
Adverse Effect :
Serious reactions: HPA axis suppression, Cushing syndrome, hyperglycemia, intracranial hypertension.
Common Reactions: Stinging, burning, pruritus, secondary infection, dryness, erythema, acneiform dermatitis, skin atrophy, leukoderma, perioral dermatitis, vesiculation, miliaria, rash, folliculitis, hypertrichosis, hypopigmentation allergic contact dermatitis, striae.
Interaction :
None.
Hepatic Dose :
No dosage adjustments are needed.