Drug Index

Terlipressin

 
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Mechanism :

Terlipressin, a synthetic triglycyl-lysine derivative of vasopressin, is an inactive prodrug. It has pressor and antidiuretic effects. Following IV injection, lysine vasopressin is released following the enzymatic cleavage of 3 glycyl moieties.


Indication :

• Acute oesophageal variceal haemorrhage

• Refractory septic shock


Contraindications :

Hypersensitivity, vascular disease esp coronary artery disease, chronic nephritis (until normal blood-nitrogen concentration attained). Pregnancy.


Dosing :

Adult: The initial recommended dose is 2 mg IV, then 1 or 2 mg 4-6 hourly until bleeding is controlled, up to 72 hour.


Adverse Effect :

Abdominal cramps, cardiac arrhythmias, headache, transient blanching, increased arterial pressure. Potentially Fatal: myocardial infarction, cardiac failure.


Interaction :

Drug Interactions Not Available.


08/11/2019 20:40:51 Terlipressin
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