Drug Index

Human Normal Immunoglobulin

Synonyms :

IGIM, Immune globulin IM

Mechanism :

HNIG is a solvent/detergent treated sterile solution of immune globulin for intramuscular administration and contains no preservative. It is prepared by cold ethanol fractionation from human plasma.


Indication :

  • Passive immunisation for
  • Measles
  • Hepatitis A
  • Varicella-zoster
  • Poliomyelitis
  • Rubella
  • Agammaglobulinemia

Contraindications :

Contraindicated in persons with isolated immunoglobulin A (IgA) deficiency. Such persons have the potential for developing antibodies to IgA and could have anaphylactic reactions to subsequent administration of blood products that contain IgA. Should not be administered to patients who have severe thrombocytopenia or any coagulation disorder that would contraindicate intramuscular injections.


Dosing :

Available as 16.5% protein/ml.
Hepatitis A:
Anticipated risk of exposure upon travel to endemic countries:
<1 month of stay: 0.1 ml/kg IM.
1-2 months of stay: 0.2 ml/kg IM. Repeat dose every 2 months for longer stays.
Post exposure prophylaxis:
0.1 ml/kg IM within 14 days of exposure for Hepatitis A exposure.
0.25 ml/kg/dose IM (not to exceed 15 ml) within 6 days of exposure for measles.
0.6-1.2 ml/kg IM within 72 hours of exposure to varicella zoster virus.

Adverse Effect :

Local pain and tenderness at the injection site, angioedema, urticaria, anaphylactic reactions.


Interaction :

MMR: Measles, mumps and rubella vaccines should not be given within 3 weeks before or 3 months after HNIG as their efficacy may be reduced.



Renal Dose :

Dose in Renal Impairment GFR (mL/min)
20-50Dose as in normal renal function
10-20Dose as in normal renal function
<10Dose as in normal renal function.

Dose in Patients undergoing Renal Replacement Therapies
CAPDNot dialysed. Dose as in normal renal function
HDNot dialysed. Dose as in normal renal function
HDF/High fluxProbably not dialysed. Dose as in normal renal function
CAV/VVHDProbably not dialysed. Dose as in normal renal function

Hepatic Dose :

No dosage adjustments are recommended.
08/11/2024 02:49:21 Human Normal Immunoglobulin
Disclaimer: The information given by www.pediatriconcall.com is provided by medical and paramedical & Health providers voluntarily for display & is meant only for informational purpose. The site does not guarantee the accuracy or authenticity of the information. Use of any information is solely at the user's own risk. The appearance of advertisement or product information in the various section in the website does not constitute an endorsement or approval by Pediatric Oncall of the quality or value of the said product or of claims made by its manufacturer.
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0