Drug Index

Hydralazine

 
print

Mechanism :

Hydralazine is an antihypertensive. Hydralazine lowers blood pressure by exerting a peripheral vasodilating effect through a direct relaxation of vascular smooth muscle. Hydralazine, by altering cellular calcium metabolism, interferes with the calcium movements within the vascular smooth muscle that are responsible for initiating or maintaining the contractile state.


Indication :

• Chronic hypertension

• Hypertensive crisis

• Severe Essential Hypertension


Contraindications :

Hypersensitivity to hydralazine; coronary artery disease; mitral valvular rheumatic heart disease are contraindications for its use.


Dosing :

Hypertensive Crisis:

3 months-12 months: 0.1-0.5 mg/kg/dose given intravenously 3-4 times a day; maximum dose is 2 mg/kg given intravenously 4 times a day. Doses must be titrated accordingly for blood pressure control.

>12 months: 0.1-0.2 mg/kg IV/IM every 4-6 hours. Can increase to 1.7-3.5 mg/kg/day in 4-6 divided doses. Max: 20 mg/dose or 200 mg/day.

Chronic Hypertension:

Start with 0.75-1 mg/kg/day given orally 2-4 times a day.

For <12 months: 5 mg/kg/day taken orally 2-4 times a day or 20 mg/dose or 200 mg/day as the maximum dose.

For >12 months: 7.5 mg/kg/day taken orally divided into 4 daily doses. Max: 200 mg/day.


Adverse Effect :

Common reactions: Fluid retention, headache, peripheral neuritis, tachycardia, palpitation.

Rare: Anemia, leukopenia, thrombocytopenia, neutropenia, SLE-like syndrome.

Serious Reactions: Hypersensitivity reaction, anaphylaxis, erythema multiforme.


Interaction :

MAO Inhibitors: Should be used with caution in patients receiving hydralazine.
Diazoxide: Profound hypotensive episodes may occur.
Beta-blockers (Metoprolol, Propranolol): Serum concentrations and pharmacologic effects may be increased.
NSAIDs: May decrease the hemodynamic effects of hydralazine; avoid use if possible or closely monitor cardiovascular status.


07/19/2019 03:07:10 Hydralazine
ask a doctor
Ask a Doctor
Disclaimer: The information given by www.pediatriconcall.com is provided by medical and paramedical & Health providers voluntarily for display & is meant only for informational purpose. The site does not guarantee the accuracy or authenticity of the information. Use of any information is solely at the user's own risk. The appearance of advertisement or product information in the various section in the website does not constitute an endorsement or approval by Pediatric Oncall of the quality or value of the said product or of claims made by its manufacturer.
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0