Hyoscine Butyl Bromide
Mechanism :
Hyoscine Butylbromide exhibits mild anticholinergic and spasmolytic atropine-like actions and possesses marked ganglionic blocking and curariform properties. Hyoscine Butylbromide is devoid of central nervous actions. Reduces peristalsis without loss of tone in peptic ulcer therapy; reduces spasm in gastrointestinal, biliary, and renal conditions.
Indication :
- Abdominal colic
- Renal colic
Contraindications :
Contraindicated in patients with myasthenia gravis, megacolon, glaucoma and in patients with known hypersensitivity to hyoscine butylbromide.
Dosing :
Oral:
5-12 years:
10 mg/dose 3-4 times daily.
12-18 years:
20 mg/dose 3-4 times daily.
IM/IV: Max: 1.2 mg/kg/day.
<6 years:
5 mg/dose 3-4 times daily.
6-12 years:
5-10 mg/dose 3-4 times daily.
>12 years:
20 mg/dose 3-4 times daily.
Adverse Effect :
Dry mouth, constipation, tachycardia, visual accommodation disturbances, and urinary retention. Less commonly: rash, itching, swelling of the hands or feet, dizziness, diarrhea, vision problems.
Interaction :
Tricyclic Antidepressants, Antihistamines, Quinidine, Amantadine, Phenothiazines, Butyrophenones and Disopyramide: Increased anticholinergic effects.
Metoclopramide: Concomitant treatment may decrease effect of both drugs on gastrointestinal tract.
Beta-agonists: Tachycardic effects may be enhanced.
Renal Dose :
Dose in Renal Impairment GFR (mL/min)
20-50 | Dose as in normal renal function |
10-20 | Dose as in normal renal function |
<10 | Dose as in normal renal function |
Dose in Patients undergoing Renal Replacement Therapies
CAPD | Dialysed. Dose as in normal renal function |
HD | Dialysed. Dose as in normal renal function |
HDF/High flux | Dialysed. Dose as in normal renal function |
CAV/VVHD | Not Dialysed. Dose as in normal renal function |