Drug Index

Hyoscine Butyl Bromide

Mechanism :

Hyoscine Butylbromide exhibits mild anticholinergic and spasmolytic atropine-like actions and possesses marked ganglionic blocking and curariform properties. Hyoscine Butylbromide is devoid of central nervous actions. Reduces peristalsis without loss of tone in peptic ulcer therapy; reduces spasm in gastrointestinal, biliary, and renal conditions.

Indication :

  • Abdominal colic
  • Renal colic

Contraindications :

Contraindicated in patients with myasthenia gravis, megacolon, glaucoma and in patients with known hypersensitivity to hyoscine butylbromide.

Dosing :

5-12 years:
10 mg/dose 3-4 times daily.
12-18 years:
20 mg/dose 3-4 times daily.
IM/IV: Max: 1.2 mg/kg/day.
<6 years:
5 mg/dose 3-4 times daily.
6-12 years:
5-10 mg/dose 3-4 times daily.
>12 years:
20 mg/dose 3-4 times daily.

Adverse Effect :

Dry mouth, constipation, tachycardia, visual accommodation disturbances, and urinary retention. Less commonly: rash, itching, swelling of the hands or feet, dizziness, diarrhea, vision problems.

Interaction :

Tricyclic Antidepressants, Antihistamines, Quinidine, Amantadine, Phenothiazines, Butyrophenones and Disopyramide: Increased anticholinergic effects.
Metoclopramide: Con­comitant treatment may decrease effect of both drugs on gastrointestinal tract.
Beta-agonists: Tachycardic ef­fects may be en­hanced.

Renal Dose :

Dose in Renal Impairment GFR (mL/min)
20-50Dose as in normal renal function
10-20Dose as in normal renal function
<10Dose as in normal renal function

Dose in Patients undergoing Renal Replacement Therapies
CAPDDialysed. Dose as in normal renal function
HDDialysed. Dose as in normal renal function
HDF/High fluxDialysed. Dose as in normal renal function
CAV/VVHDNot Dialysed. Dose as in normal renal function
12/24/2023 09:31:34 Hyoscine Butyl Bromide
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