Drug Index

Idursulfase

 
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Mechanism :

Idursulfase is a recombinant form of iduronate-2-sulfatase, an enzyme needed to hydrolyse the mucopolysaccharides dermatan sulfate and heparan sulfate in various cells.


Indication :

• Enzyme replacement therapy in Hunter syndrome (Mucopolysaccharidosis II, MPS)


Contraindications :

Hypersensitivity to idursulfase or any component of the formulation.


Dosing :

Children ≥5 years and Adolescents: IV 0.5 mg/kg once weekly.


Adverse Effect :

Flushing, headache, fatigue, skin rash, pruritus, vomiting, hypersensitivity reactions, antibody development, musculoskeletal pain, pneumonia, fever, tachycardia, hypotension, chills, angioedema.


Interaction :

No known significant interactions.


07/13/2019 00:53:55 Idursulfase
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