Idursulfase
Mechanism :
Idursulfase is a recombinant form of iduronate-2-sulfatase, an enzyme needed to hydrolyse the mucopolysaccharides dermatan sulfate and heparan sulfate in various cells.
Indication :
- Enzyme replacement therapy in Hunter syndrome (Mucopolysaccharidosis II, MPS)
Contraindications :
Hypersensitivity to idursulfase or any component of the formulation.
Dosing :
Children ≥5 years and Adolescents:
IV 0.5 mg/kg once weekly.
Adverse Effect :
Flushing, headache, fatigue, skin rash, pruritus, vomiting, hypersensitivity reactions, antibody development, musculoskeletal pain, pneumonia, fever, tachycardia, hypotension, chills, angioedema.
Interaction :
No known significant interactions.
Hepatic Dose :
No dose adjustments are recommended.