Drug Index


Mechanism :

Idursulfase is a recombinant form of iduronate-2-sulfatase, an enzyme needed to hydrolyse the mucopolysaccharides dermatan sulfate and heparan sulfate in various cells.

Indication :

  • Enzyme replacement therapy in Hunter syndrome (Mucopolysaccharidosis II, MPS)

Contraindications :

Hypersensitivity to idursulfase or any component of the formulation.

Dosing :

Children ≥5 years and Adolescents:
IV 0.5 mg/kg once weekly.

Adverse Effect :

Flushing, headache, fatigue, skin rash, pruritus, vomiting, hypersensitivity reactions, antibody development, musculoskeletal pain, pneumonia, fever, tachycardia, hypotension, chills, angioedema.

Interaction :

No known significant interactions.

Hepatic Dose :

No dose adjustments are recommended.
02/21/2024 23:50:57 Idursulfase
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