Drug Index

Levocetirizine

 
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Mechanism :

Levocetirizine works by blocking histamine receptors. It does not prevent the actual release of histamine from mast cells, but prevents it binding to its receptors. This in turn prevents the release of other allergy chemicals and increased blood supply to the area and provides relief from the typical symptoms of hay fever.


Indication :

• Seasonal allergic rhinitis

• Perennial allergic rhinitis

• Chronic idiopathic urticaria


Contraindications :

Hypersensitivity to drug/class/component, End Stage Renal Disease, Hemodialysis, Renal impairment (6 mo-11 yo pts).

Caution if renal impairment, CNS depressant use, alcohol use, prostatic hypertrophy, spinal cord injury.


Dosing :

Safety and efficacy not established in children under 6 months of age.

6 months-5 years: 1.25 mg orally in the evening.

6-12 years: 2.5 mg orally in the evening.

>12 years: 2.5-5 mg orally in the evening.


Adverse Effect :

Common Reactions: Somnolence, fatigue, asthenia, urinary retention, nasopharyngitis, xerostomia, fever, diarrhea, vomiting, cough, pharyngitis, otitis media, epistaxis

Serious Reactions: Anaphylaxis, hypersensitivity reaction, seizures.


Interaction :

Avoid/Use Alternative:
Doxylamine
Caution Advised:
Acrivastine, Aldesleukin, Alfentanil, Alprazolam, Amitriptyline, Amoxapine, Apomorphine, Aripiprazole, Asenapine, Azelastine Nasal, Baclofen, Baclofen Intrathecal, Brompheniramine, Buprenorphine, Butabarbital, Butalbital, Butorphanol, Butorphanol Nasal, Calendula, Capsicum, Carbamazepine, Carbinoxamine, Carisoprodol, Cetirizine, Chamomile German, Chloral Hydrate, Chlordiazepoxide, Chlorpheniramine, Chlorpromazine, Chlorzoxazone, Clemastine, Clobazam, Clomipramine, Clonazepam, Clonidine, Clorazepate, Clozapine, Codeine, Cyclizine, Cyclobenzaprine, Cyproheptadine, Dantrolene, Desipramine, Dexchlorpheniramine, Dexmedetomidine, Diazepam, Dichloralphenazone, Dihydrocodeine, Dimenhydrinate, Diphenhydramine, Doxepin, Dronabinol, Droperidol, Estazolam, Eszopiclone, Ethanol, Ethosuximide, Etomidate, Ezogabine, Fentanyl, Fluphenazine, Flurazepam, Fosphenytoin, Fospropofol, Gabapentin, Gabapentin Enacarbil, Ginseng Siberian, Goldenseal, Gotu Kola, Guanabenz, Guanfacine, Haloperidol, Hawthorn, Hydrocodone, Hydromorphone, Hydroxyzine, Iloperidone, Imipramine, Kava, Ketamine, Lemon Balm, Levorphanol, Lorazepam, Loxapine, Lurasidone, Maprotiline, Meclizine, Melatonin, Meperidine, Meprobamate, Metaxalone, Methadone, Methocarbamol, Methohexital, Methyldopa, Metoclopramide, Midazolam, Mirtazapine, Mitotane, Morphine, Morphine Liposomal, Nabilone, Nalbuphine, Nefazodone, Nortriptyline, Olanzapine, Olopatadine Nasal, Orphenadrine, Oxazepam, Oxcarbazepine, Oxybutynin, Oxycodone, Oxymorphone, Paliperidone, Passionflower, Pentazocine, Pentobarbital, Perampanel, Perphenazine, Pheniramine, Phenobarbital, Phenytoin, Pimozide, Pramipexole, Pregabalin, Primidone, Prochlorperazine, Promethazine, Propofol, Protriptyline, Pyrilamine, Quetiapine, Remifentanil, Risperidone, Ropinirole, Rotigotine Transdermal, Rufinamide, Secobarbital, Sodium Oxybate, Sufentanil, Tapentadol, Temazepam, Tetrabenazine, Thalidomide, Thioridazine, Thiothixene, Tiagabine, Tizanidine, Tolcapone, Topiramate, Tramadol, Trazodone, Triazolam, Trifluoperazine, Trimipramine, Triprolidine, Valerian, Valproic Acid, Vigabatrin, Zaleplon, Ziconotide, Ziprasidone, Zolpidem, Zonisamide.



Renal Dose :

Dose in Renal Impairment GFR (mL/min)
30-505 mg every 48 hours.
10-305 mg every 72 hours.
<105 mg every 72 hours.

Dose in Patients undergoing Renal Replacement Therapies
CAPDUnlikely dialysability. Dose as in GFR<10 mL/min
HDNot dialysed. Dose as in GFR<10 mL/min
HDF/High fluxUnknown dialysability. Dose as in GFR<10 mL/min
CAV/VVHDUnlikely dialysability. Dose as in GFR=10–30 mL/min

Hepatic Dose :

No dose adjustments are recommended.
05/21/2020 21:32:35 Levocetirizine
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