Drug Index


Mechanism :

Levocetirizine works by blocking histamine receptors. It does not prevent the actual release of histamine from mast cells, but prevents it binding to its receptors. This in turn prevents the release of other allergy chemicals and increased blood supply to the area and provides relief from the typical symptoms of hay fever.

Indication :

  • Seasonal allergic rhinitis
  • Perennial allergic rhinitis
  • Chronic idiopathic urticaria

Contraindications :

Hypersensitivity to drug/class/component, End Stage Renal Disease, Hemodialysis, Renal impairment (6 mo-11 yo pts).

Caution if renal impairment, CNS depressant use, alcohol use, prostatic hypertrophy, spinal cord injury.

Dosing :

Safety and efficacy not established in children under 6 months of age.
6 months-5 years:
1.25 mg orally in the evening.
6-12 years:
2.5 mg orally in the evening.
>12 years:
2.5-5 mg orally in the evening.

Adverse Effect :

Common Reactions: Somnolence, fatigue, asthenia, urinary retention, nasopharyngitis, xerostomia, fever, diarrhea, vomiting, cough, pharyngitis, otitis media, epistaxis

Serious Reactions: Anaphylaxis, hypersensitivity reaction, seizures.

Interaction :

Avoid/Use Alternative:
Caution Advised:
Acrivastine, Aldesleukin, Alfentanil, Alprazolam, Amitriptyline, Amoxapine, Apomorphine, Aripiprazole, Asenapine, Azelastine Nasal, Baclofen, Baclofen Intrathecal, Brompheniramine, Buprenorphine, Butabarbital, Butalbital, Butorphanol, Butorphanol Nasal, Calendula, Capsicum, Carbamazepine, Carbinoxamine, Carisoprodol, Cetirizine, Chamomile German, Chloral Hydrate, Chlordiazepoxide, Chlorpheniramine, Chlorpromazine, Chlorzoxazone, Clemastine, Clobazam, Clomipramine, Clonazepam, Clonidine, Clorazepate, Clozapine, Codeine, Cyclizine, Cyclobenzaprine, Cyproheptadine, Dantrolene, Desipramine, Dexchlorpheniramine, Dexmedetomidine, Diazepam, Dichloralphenazone, Dihydrocodeine, Dimenhydrinate, Diphenhydramine, Doxepin, Dronabinol, Droperidol, Estazolam, Eszopiclone, Ethanol, Ethosuximide, Etomidate, Ezogabine, Fentanyl, Fluphenazine, Flurazepam, Fosphenytoin, Fospropofol, Gabapentin, Gabapentin Enacarbil, Ginseng Siberian, Goldenseal, Gotu Kola, Guanabenz, Guanfacine, Haloperidol, Hawthorn, Hydrocodone, Hydromorphone, Hydroxyzine, Iloperidone, Imipramine, Kava, Ketamine, Lemon Balm, Levorphanol, Lorazepam, Loxapine, Lurasidone, Maprotiline, Meclizine, Melatonin, Meperidine, Meprobamate, Metaxalone, Methadone, Methocarbamol, Methohexital, Methyldopa, Metoclopramide, Midazolam, Mirtazapine, Mitotane, Morphine, Morphine Liposomal, Nabilone, Nalbuphine, Nefazodone, Nortriptyline, Olanzapine, Olopatadine Nasal, Orphenadrine, Oxazepam, Oxcarbazepine, Oxybutynin, Oxycodone, Oxymorphone, Paliperidone, Passionflower, Pentazocine, Pentobarbital, Perampanel, Perphenazine, Pheniramine, Phenobarbital, Phenytoin, Pimozide, Pramipexole, Pregabalin, Primidone, Prochlorperazine, Promethazine, Propofol, Protriptyline, Pyrilamine, Quetiapine, Remifentanil, Risperidone, Ropinirole, Rotigotine Transdermal, Rufinamide, Secobarbital, Sodium Oxybate, Sufentanil, Tapentadol, Temazepam, Tetrabenazine, Thalidomide, Thioridazine, Thiothixene, Tiagabine, Tizanidine, Tolcapone, Topiramate, Tramadol, Trazodone, Triazolam, Trifluoperazine, Trimipramine, Triprolidine, Valerian, Valproic Acid, Vigabatrin, Zaleplon, Ziconotide, Ziprasidone, Zolpidem, Zonisamide.

Renal Dose :

Dose in Renal Impairment GFR (mL/min)
30-505 mg every 48 hours.
10-305 mg every 72 hours.
<105 mg every 72 hours.

Dose in Patients undergoing Renal Replacement Therapies
CAPDUnlikely dialysability. Dose as in GFR<10 mL/min
HDNot dialysed. Dose as in GFR<10 mL/min
HDF/High fluxUnknown dialysability. Dose as in GFR<10 mL/min
CAV/VVHDUnlikely dialysability. Dose as in GFR=10–30 mL/min

Hepatic Dose :

No dose adjustments are recommended.
12/21/2023 20:23:00 Levocetirizine
Disclaimer: The information given by www.pediatriconcall.com is provided by medical and paramedical & Health providers voluntarily for display & is meant only for informational purpose. The site does not guarantee the accuracy or authenticity of the information. Use of any information is solely at the user's own risk. The appearance of advertisement or product information in the various section in the website does not constitute an endorsement or approval by Pediatric Oncall of the quality or value of the said product or of claims made by its manufacturer.
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0