Levocetirizine

Mechanism :

Levocetirizine works by blocking histamine receptors. It does not prevent the actual release of histamine from mast cells, but prevents it binding to its receptors. This in turn prevents the release of other allergy chemicals and increased blood supply to the area and provides relief from the typical symptoms of hay fever.

Indication :

• Seasonal allergic rhinitis
• Perennial allergic rhinitis
• Chronic idiopathic urticaria

Contraindications :

Hypersensitivity to drug/class/component, End Stage Renal Disease, Hemodialysis, Renal impairment (6 mo-11 yo pts).

Caution if renal impairment, CNS depressant use, alcohol use, prostatic hypertrophy, spinal cord injury.

Dosing :

Adverse Effect :

Common Reactions: Somnolence, fatigue, asthenia, urinary retention, nasopharyngitis, xerostomia, fever, diarrhea, vomiting, cough, pharyngitis, otitis media, epistaxis

Serious Reactions: Anaphylaxis, hypersensitivity reaction, seizures.

Interaction :

Avoid/Use Alternative:
Doxylamine
Caution Advised:
Acrivastine, Aldesleukin, Alfentanil, Alprazolam, Amitriptyline, Amoxapine, Apomorphine, Aripiprazole, Asenapine, Azelastine Nasal, Baclofen, Baclofen Intrathecal, Brompheniramine, Buprenorphine, Butabarbital, Butalbital, Butorphanol, Butorphanol Nasal, Calendula, Capsicum, Carbamazepine, Carbinoxamine, Carisoprodol, Cetirizine, Chamomile German, Chloral Hydrate, Chlordiazepoxide, Chlorpheniramine, Chlorpromazine, Chlorzoxazone, Clemastine, Clobazam, Clomipramine, Clonazepam, Clonidine, Clorazepate, Clozapine, Codeine, Cyclizine, Cyclobenzaprine, Cyproheptadine, Dantrolene, Desipramine, Dexchlorpheniramine, Dexmedetomidine, Diazepam, Dichloralphenazone, Dihydrocodeine, Dimenhydrinate, Diphenhydramine, Doxepin, Dronabinol, Droperidol, Estazolam, Eszopiclone, Ethanol, Ethosuximide, Etomidate, Ezogabine, Fentanyl, Fluphenazine, Flurazepam, Fosphenytoin, Fospropofol, Gabapentin, Gabapentin Enacarbil, Ginseng Siberian, Goldenseal, Gotu Kola, Guanabenz, Guanfacine, Haloperidol, Hawthorn, Hydrocodone, Hydromorphone, Hydroxyzine, Iloperidone, Imipramine, Kava, Ketamine, Lemon Balm, Levorphanol, Lorazepam, Loxapine, Lurasidone, Maprotiline, Meclizine, Melatonin, Meperidine, Meprobamate, Metaxalone, Methadone, Methocarbamol, Methohexital, Methyldopa, Metoclopramide, Midazolam, Mirtazapine, Mitotane, Morphine, Morphine Liposomal, Nabilone, Nalbuphine, Nefazodone, Nortriptyline, Olanzapine, Olopatadine Nasal, Orphenadrine, Oxazepam, Oxcarbazepine, Oxybutynin, Oxycodone, Oxymorphone, Paliperidone, Passionflower, Pentazocine, Pentobarbital, Perampanel, Perphenazine, Pheniramine, Phenobarbital, Phenytoin, Pimozide, Pramipexole, Pregabalin, Primidone, Prochlorperazine, Promethazine, Propofol, Protriptyline, Pyrilamine, Quetiapine, Remifentanil, Risperidone, Ropinirole, Rotigotine Transdermal, Rufinamide, Secobarbital, Sodium Oxybate, Sufentanil, Tapentadol, Temazepam, Tetrabenazine, Thalidomide, Thioridazine, Thiothixene, Tiagabine, Tizanidine, Tolcapone, Topiramate, Tramadol, Trazodone, Triazolam, Trifluoperazine, Trimipramine, Triprolidine, Valerian, Valproic Acid, Vigabatrin, Zaleplon, Ziconotide, Ziprasidone, Zolpidem, Zonisamide.

Renal Dose :

Hepatic Dose :