Drug Index


Mechanism :

Melarsoprol is a trivalent arsenical compound that irreversibly binds to vicinal sulfhydryl groups on pyruvate kinase, which disrupts energy production in the parasite.

Indication :

  • African Trypanosomiasis (Sleeping Sickness):Used for the treatment of late stages of T. b. gambiense and T. b. rhodesiense infections involving the CNS.

Contraindications :

Glucose-6-phosphate dehydrogenase (G6PD) deficiency, hypersensitivity.

Dosing :

18-25 mg/kg total over 1 month. Initial 0.36 mg/kg IV followed by gradually increasing to 3.6 mg/kg IV at intervals of 1-5 days for total of 9-10 doses.

Adverse Effect :

Glucose-6-phosphate dehydrogenase (G6PD) deficiency, hypersensitivity.

Hypertension, myocardial damage, encephalopathy, peripheral neuropathy, colic, vomiting, albuminuria, herxheimer-type reaction, arsenic encephalopathy.

Hepatic Dose :

No dosage adjustments are recommended.
02/20/2024 23:24:58 Melarsoprol
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